Trial reportAmerican journal of respiratory and critical care medicine2021
Protocolized Postextubation Respiratory Support to Prevent Reintubation: A Randomized Clinical Trial.
Open access · greenAbstract readPragmatic Clinical TrialRandomized Controlled Trial
In one paragraph
Trial report in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- High-Flow Nasal Cannula Versus Noninvasive Ventilation for Prevention of Reintubation in High-Risk Critically Ill Patients (HIGH-FLOW OXY): An Informative Systematic Review and Meta-Analysis.Critical care explorations · 2026Pooled it
- Noninvasive respiratory support following extubation in critically ill adults: a systematic review and network meta-analysis.Intensive care medicine · 2022Pooled it
- Effectiveness of high-flow nasal cannulae compared with noninvasive positive-pressure ventilation in preventing reintubation in patients receiving prolonged mechanical ventilation.Scientific reports · 2023Trial
- Effect of postextubation noninvasive ventilation with active humidification vs high-flow nasal cannula on reintubation in patients at very high risk for extubation failure: a randomized trial.Intensive care medicine · 2022Trial
- Review
- Spontaneous breathing trials as predictors of extubation outcomes in neurocritical care: insights from the ENIO study.Intensive care medicine · 2026Observational
- The ability of diaphragmatic excursion after extubation to predict the need for resumption of ventilatory support in critically ill surgical patients.Journal of anesthesia · 2025Observational
- Protocol for the development of a guideline on post-extubation respiratory support for mechanically ventilated patients in the ICU.BMJ open · 2025Article
- Article
- Optimal Postextubation Support in Critically Ill Patients: One Size Does Not Fit All.Respiratory care · 2024Review
- Ability of parasternal intercostal muscle thickening fraction to predict reintubation in surgical patients with sepsis.BMC anesthesiology · 2024Observational
- Peripheral perfusion index as a predictor of reintubation in critically ill surgical patients.BMC anesthesiology · 2024Observational
- Effectiveness of high flow nasal cannula (HFNC) versus bilevel positive airway pressure (BiPAP) in preventing tracheal reintubation in patients with high risk of extubation failure in intensive care unit - A randomised comparative trial.Indian journal of anaesthesia · 2024Article
- Effect of prophylactic noninvasive oxygen therapy after planned extubation on extubation failure in high-risk patients: a retrospective propensity score-matched cohort study.Frontiers in medicine · 2024Article
- Personalized Noninvasive Respiratory Support in the Perioperative Setting: State of the Art and Future Perspectives.Journal of personalized medicine · 2023Review
- To Intubate or Not Intubate, That Is the Question.American journal of respiratory and critical care medicine · 2023Article
- Postextubation Respiratory Support: One More Piece to the Puzzle.American journal of respiratory and critical care medicine · 2022Article
- Benefit with preventive noninvasive ventilation in subgroups of patients at high-risk for reintubation: a post hoc analysis.Journal of intensive care · 2022Article
- Prediction Model of Extubation Outcomes in Critically Ill Patients: A Multicenter Prospective Cohort Study.Journal of clinical medicine · 2022Article
- The Respiratory Rate-Oxygenation Index predicts failure of post-extubation high-flow nasal cannula therapy in intensive care unit patients: a retrospective cohort study.Revista Brasileira de terapia intensiva · 2022Observational
Corrections and comments
- Commented on by
Authors and funding
19 authors at 5 institutions in 1 country.
Jonathan D CaseyDivision of Allergy, Pulmonary, and Critical Care Medicine.ORCID 0000-0002-0977-290X
Erin M VaughanDivision of Allergy, Pulmonary, and Critical Care Medicine.
Bradley D LloydDivision of Respiratory Care.
Peter A BillasDepartment of Anesthesiology, University of Florida, Gainesville, Florida.
Karen E JacksonDivision of Allergy, Pulmonary, and Critical Care Medicine.
Eric J HallDepartment of Internal Medicine.
Alexandra H ToporekDepartment of Internal Medicine.
Kevin G BuellDepartment of Internal Medicine.
Ryan M BrownDivision of Allergy, Pulmonary, and Critical Care Medicine.ORCID 0000-0002-8778-026X
Roger K RichardsonDivision of Respiratory Care.
J Craig RooksDivision of Respiratory Care.
Reagan B BuieVanderbilt Institute for Clinical and Translational Research.
Li WangDepartment of Biostatistics.
Christopher J LindsellDepartment of Biostatistics.
E Wesley ElyDivision of Allergy, Pulmonary, and Critical Care Medicine.
Wesley H SelfDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; and.
Gordon R BernardDivision of Allergy, Pulmonary, and Critical Care Medicine.
Todd W RiceDivision of Allergy, Pulmonary, and Critical Care Medicine.
Matthew W SemlerDivision of Allergy, Pulmonary, and Critical Care Medicine.ORCID 0000-0002-7664-8263
Pulmonary and Allergy Associates · USCancer Research And Biostatistics · USGeriatric Research Education and Clinical Center · USUniversity of Florida · USVanderbilt University Medical Center · US
Funding
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MVANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MClinical and Translational Training Program in Pulmonary MedicineT32HL087738 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lorraine B Ware · 2007 to 2026
$7.0MThe Vanderbilt Emergency Care Research Training ProgramK12HL133117 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STORROW, ALAN B · 2016 to 2020
$1.9MBag-Mask Ventilation to PreVent Hypoxemia during Tracheal Intubation in the Emergency Department: A Clinical TrialK23HL153584 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASEY, JONATHAN DALE · 2020 to 2024
$900kOxygen Saturation Targets during Mechanical Ventilation of Critically Ill Adults: A Clinical TrialK23HL143053 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SEMLER, MATTHEW WALL · 2018 to 2022
$854kNCATS NIH HHS UL1 TR002243NCRR NIH HHS UL1 RR024975NHLBI NIH HHS K12 HL133117NHLBI NIH HHS K23 HL143053NHLBI NIH HHS K23 HL153584NHLBI NIH HHS T32 HL087738
Abstract
PubMed holds no abstract for this paper.
Indexed as
CannulaAdultAgedAirway ExtubationClinical ProtocolsConsciousness DisordersCross-Over StudiesFemaleHumansHypercapniaHypoxiaIntensive Care UnitsIntubation, IntratrachealMaleMiddle AgedNoninvasive Ventilationinvasive mechanical ventilationnoninvasive respiratory supportreintubation
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.