ArticlePlant physiology2021
Heat stress interferes with formation of double-strand breaks and homolog synapsis.
Article in Plant physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Reproductive thermotolerance: from flower development to seed initiation.The New phytologist · 2026Review
- The meiotic achilles' heel: vulnerability and resilience under environmental stress.Protoplasma · 2026Review
- Anther and pollen thermotolerance: molecular mechanisms and implications for plant reproduction under heat stress.Planta · 2026Review
- Article
- Meiotic cytokinesis defects in cultured Arabidopsis flowers induce diploid microspores.Plant reproduction · 2025Article
- Molecular aspects of heat stress sensing in land plants.The Plant journal : for cell and molecular biology · 2025Review
- Arabidopsis accessions and their difference in heat tolerance during meiosis.Plant physiology · 2025Article
- The plant early recombinosome: a high security complex to break DNA during meiosis.Plant reproduction · 2024Review
- Article
- Mechanistic insights into DNA damage recognition and checkpoint control in plants.Nature plants · 2024Review
- Genomic regions and biological mechanisms underlying climatic resilience traits derived from automatically-recorded vaginal temperature in lactating sows under heat stress conditions.Frontiers in genetics · 2024Article
- Various tomato cultivars display contrasting morphological and molecular responses to a chronic heat stress.Frontiers in plant science · 2023Article
- Asynapsis and meiotic restitution in tomato male meiosis induced by heat stress.Frontiers in plant science · 2023Article
- Meiotic chromosome organization and its role in recombination and cancer.Current topics in developmental biology · 2023Review
- Heat shock protein 101 contributes to the thermotolerance of male meiosis in maize.The Plant cell · 2022Article
- Advances and Perspectives for Polyploidy Breeding in Orchids.Plants (Basel, Switzerland) · 2022Review
- Interfered chromosome pairing at high temperature promotes meiotic instability in autotetraploid Arabidopsis.Plant physiology · 2022Article
- Long-Term Mild Heat Causes Post-Mitotic Pollen Abortion Through a Local Effect on Flowers.Frontiers in plant science · 2022Article
- Architecture and plasticity: optimizing plant performance in dynamic environments.Plant physiology · 2021Article
- Comparative transcriptomic analysis of thermally stressed Arabidopsis thaliana meiotic recombination mutants.BMC genomics · 2021Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meiotic recombination (MR) drives novel combinations of alleles and contributes to genomic diversity in eukaryotes. In this study, we showed that heat stress (36°C-38°C) over the fertile threshold fully abolished crossover formation in Arabidopsis (Arabidopsis thaliana). Cytological and genetic studies in wild-type plants and syn1 and rad51 mutants suggested that heat stress reduces generation of SPO11-dependent double-strand breaks (DSBs). In support, the abundance of recombinase DMC1, which is required for MR-specific DSB repair, was significantly reduced under heat stress. In addition, high temperatures induced disassembly and/or instability of the ASY4- but not the SYN1-mediated chromosome axis. At the same time, the ASY1-associated lateral element of the synaptonemal complex (SC) was partially affected, while the ZYP1-dependent central element of SC was disrupted, indicating that heat stress impairs SC formation. Moreover, expression of genes involved in DSB formation; e.g. SPO11-1, PRD1, 2, and 3 was not impacted; however, recombinase RAD51 and chromosome axis factors ASY3 and ASY4 were significantly downregulated under heat stress. Taken together, these findings revealed that heat stress inhibits MR via compromised DSB formation and homolog synapsis, which are possible downstream effects of the impacted chromosome axis. Our study thus provides evidence shedding light on how increasing environmental temperature influences MR in Arabidopsis.
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