ArticlePlant physiology2021
Kingdom-wide analysis of the evolution of the plant type III polyketide synthase superfamily.
Article in Plant physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Integrative structural and physicochemical characterization of chalcone synthase enzymes from medicinal plants using AlphaFold, molecular docking, and molecular dynamics.Scientific reports · 2026Article
- Genome-Wide Identification, Molecular Evolution, and Expression Divergence ofFood science & nutrition · 2025Article
- Characterization and functional analysis of type III polyketide synthases in Selaginella moellendorffii.Planta · 2025Article
- Australian Rainforests-A Living Museum of Natural Product Chemical Diversity.Progress in the chemistry of organic natural products · 2025Review
- Evolutionary landscape of plant chalcone isomerase-fold gene families.Frontiers in plant science · 2025Article
- Evolution of plant metabolism: the state-of-the-art.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Phylogenomic and synteny analysis of BAHD and SCP/SCPL gene families reveal their evolutionary histories in plant specialized metabolism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Unveiling the Catalytic Roles ofMolecules (Basel, Switzerland) · 2024Article
- Designing a highly efficient type III polyketide whole-cell catalyst with minimized byproduct formation.Biotechnology for biofuels and bioproducts · 2024Article
- A chromosome-level genome reveals genome evolution and molecular basis of anthraquinone biosynthesis in Rheum palmatum.BMC plant biology · 2024Article
- A hybrid pathway for self-sustained luminescence.Science advances · 2024Article
- Haplotype-phased genome unveils the butylphthalide biosynthesis and homoploid hybrid origin ofScience advances · 2024Article
- The Stilbene Synthase Family inGenes · 2023Article
- Parallel evolution of cannabinoid biosynthesis.Nature plants · 2023Article
- All roads lead to Rome: alternative biosynthetic routes in plant specialised metabolism.The New phytologist · 2023Article
- Evolution and function of red pigmentation in land plants.Annals of botany · 2022Review
- Polyketide reductases in defense-related parasorboside biosynthesis in Gerbera hybrida share processing strategies with microbial polyketide synthase systems.The New phytologist · 2022Article
- A Systematic Phylogenomic Classification of the Multidrug and Toxic Compound Extrusion Transporter Gene Family in Plants.Frontiers in plant science · 2022Article
- Ancestral sequence reconstruction - An underused approach to understand the evolution of gene function in plants?Computational and structural biotechnology journal · 2021Review
- Diversity of Chemical Structures and Biosynthesis of Polyphenols in Nut-Bearing Species.Frontiers in plant science · 2021Review
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The emergence of type III polyketide synthases (PKSs) was a prerequisite for the conquest of land by the green lineage. Within the PKS superfamily, chalcone synthases (CHSs) provide the entry point reaction to the flavonoid pathway, while LESS ADHESIVE POLLEN 5 and 6 (LAP5/6) provide constituents of the outer exine pollen wall. To study the deep evolutionary history of this key family, we conducted phylogenomic synteny network and phylogenetic analyses of whole-genome data from 126 species spanning the green lineage including Arabidopsis thaliana, tomato (Solanum lycopersicum), and maize (Zea mays). This study thereby combined study of genomic location and context with changes in gene sequences. We found that the two major clades, CHS and LAP5/6 homologs, evolved early by a segmental duplication event prior to the divergence of Bryophytes and Tracheophytes. We propose that the macroevolution of the type III PKS superfamily is governed by whole-genome duplications and triplications. The combined phylogenetic and synteny analyses in this study provide insights into changes in the genomic location and context that are retained for a longer time scale with more recent functional divergence captured by gene sequence alterations.
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