ArticleThe Plant cell2021
Two interacting ethylene response factors regulate heat stress response.
Article in The Plant cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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Who cites it
86 citing papers in PubMed, 158 citations in OpenAlex.
- Thermal priming enhances yield after recurrent heat stress and involves SlHSFA2-SlERFs in the regulation of transcriptional thermal memory in tomato.The Plant journal : for cell and molecular biology · 2026Article
- Effect of High Temperature and Drought on the Fatty Acid Composition of Oil of Different Linseed Varieties and Its Association with Gene Expression.International journal of molecular sciences · 2026Article
- Principles and mechanisms of plant acclimation to heat stress.Nature reviews. Molecular cell biology · 2026Review
- Advances in Physiological and Molecular Mechanisms of Heat Stress in Apple and Pear.Plants (Basel, Switzerland) · 2026Review
- Rice ethylene receptors OsERS1/2 function as CaPlant communications · 2026Article
- An ethylene-responsive element with spatial bias in Arabidopsis.Molecular biology reports · 2026Article
- Identification of Genetic Variation Associated With Heat Tolerance in Cowpea (Vigna unguiculata L. Walp.).Molecular ecology · 2026Article
- Genome-wide identification and expression analysis of the Hsf gene family in Rhododendron molle under heat stress.Genes & genomics · 2026Article
- Multi-omics Analysis Reveals the Hormonal Basis of Differential Response to Nighttime Heat Temperature Between Superior and Inferior Rice Grains.Rice (New York, N.Y.) · 2026Article
- The DREB2C.L-IAGLU module contributes to long-term heat stress via sugar metabolism in cucumber.Horticulture research · 2026Article
- Molecular mechanisms and breeding strategies for heat tolerance in vegetable crops under global warming.Horticulture research · 2026Article
- Root-Specific Signal Modules Mediating Abiotic Stress Tolerance in Fruit Crops.Plants (Basel, Switzerland) · 2026Review
- Transcriptomic analysis of reduced thermotolerance inFrontiers in plant science · 2026Article
- Combined transcriptomics and metabolomics analysis reveals the molecular responses of heat tolerance during germination stage in sesame.Frontiers in plant science · 2026Article
- Review
- Molecular Mechanisms of the Phytohormone-Heat Shock Protein Pathway in Regulating Plant Thermotolerance.Plants (Basel, Switzerland) · 2025Review
- An Ethylene-Response Factor LlERF092 Coordinates With LlETO1 to Improve Thermotolerance by Activating LlMBF1c in Lily.Plant biotechnology journal · 2025Article
- Genome-wide expression atlas of tomato flower buds revealed theHorticulture research · 2025Article
- Transcription factors ERF74/77/108/125 enhance thermotolerance in rice by regulating common and distinct heat-responsive gene expression.Plant biotechnology journal · 2025Article
- Protein networks: integrating pathways for plant heat stress adaptation.Functional & integrative genomics · 2025Review
26 more citing papers are in PubMed but not listed here.
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5 authors at 2 institutions in 2 countries.
Funding
Abstract
The ethylene response factor (ERF) transcription factors are integral components of environmental stress signaling cascades, regulating a wide variety of downstream genes related to stress responses and plant development. However, the mechanisms by which ERF genes regulate the heat stress response are not well understood. Here, we uncover the positive role of ethylene signaling, ERF95 and ERF97 in basal thermotolerance of Arabidopsis thaliana. We demonstrate that ethylene signaling-defective mutants exhibit compromised basal thermotolerance, whereas plants with constitutively activated ethylene response show enhanced basal thermotolerance. EIN3 physically binds to the promoters of ERF95 and ERF97. Ectopic constitutive expression of ERF95 or ERF97 increases the basal thermotolerance of plants. In contrast, erf95 erf96 erf97 erf98 quadruple mutants exhibit decreased basal thermotolerance. ERF95 and ERF97 genetically function downstream of EIN3. ERF95 can physically interact with ERF97, and this interaction is heat inducible. ERF95 and ERF97 regulate a common set of target genes, including known heat-responsive genes and directly bind to the promoter of HSFA2. Thus, our study reveals that the EIN3-ERF95/ERF97-HSFA2 transcriptional cascade may play an important role in the heat stress response, thereby establishing a connection between ethylene and its downstream regulation in basal thermotolerance of plants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.