ArticleThe Plant cell2021
EIN2-directed histone acetylation requires EIN3-mediated positive feedback regulation in response to ethylene.
Article in The Plant cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 72 citations in OpenAlex.
- EBSn, a Robust Synthetic Reporter for Monitoring Ethylene Responses in Plants.Plant biotechnology journal · 2026Article
- Evolutionary Divergence of an Ethylene-Responsive Transcriptional Cascade Governs a Dose-Dependent Balance between Cotton Fiber Length and Strength.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The 14-3-3 Protein SlTFT1 Accelerates Tomato Fruit Ripening by Binding and Stabilising YFT1 in the Ethylene Signalling Pathway.Plant biotechnology journal · 2025Article
- Studies on the mother flower carnation: past, present, and future.Horticulture research · 2025Article
- Histone acetyltransferase HAF2 associates with pyruvate dehydrogenase complex to control H3K14ac and H3K23ac in ethylene response.Cell reports · 2025Article
- Integrative transcriptomic and physiological analyses uncover mechanisms by which arbuscular mycorrhizal fungi mitigate salt stress in sugar beet.Mycorrhiza · 2025Article
- mRNA mGenome biology · 2025Article
- Constitutive expression of cucumber CsACS2 in Arabidopsis Thaliana disrupts anther dehiscence through ethylene signaling and DNA methylation pathways.Plant cell reports · 2024Article
- How chromatin senses plant hormones.Current opinion in plant biology · 2024Review
- LHP1 and INO80 cooperate with ethylene signaling for warm ambient temperature response by activating specific bivalent genes.Cell reports · 2024Article
- Ethylene, a Signaling Compound Involved in Seed Germination and Dormancy.Plants (Basel, Switzerland) · 2024Review
- Epigenetics and plant hormone dynamics: a functional and methodological perspective.Journal of experimental botany · 2024Review
- A ribonuclease T2 protein FocRnt2 contributes to the virulence of Fusarium oxysporum f. sp. cubense tropical race 4.Molecular plant pathology · 2024Article
- Nuclear pyruvate dehydrogenase complex regulates histone acetylation and transcriptional regulation in the ethylene response.Science advances · 2024Article
- Factors Influencing Seed Dormancy and Germination and Advances in Seed Priming Technology.Plants (Basel, Switzerland) · 2024Review
- Endoribonuclease DNE1 Promotes Ethylene Response by ModulatingInternational journal of molecular sciences · 2024Article
- DNA methylation remodeled amino acids biosynthesis regulates flower senescence in carnation (Dianthus caryophyllus).The New phytologist · 2024Article
- An insertion of transposon in DcNAP inverted its function in the ethylene pathway to delay petal senescence in carnation (Dianthus caryophyllus L.).Plant biotechnology journal · 2023Article
- Multiplex CRISPR-Cas9 knockout of EIL3, EIL4, and EIN2L advances soybean flowering time and pod set.BMC plant biology · 2023Article
- A translational regulator MHZ9 modulates ethylene signaling in rice.Nature communications · 2023Article
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9 authors at 1 institution in 1 country.
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Abstract
Ethylene is an important phytohormone with pleotropic roles in plant growth, development, and stress responses. ETHYLENE INSENSITIVE2 (EIN2) mediates the transduction of the ethylene signal from the endoplasmic reticulum membrane to the nucleus, where its C-terminus (EIN2-C) regulates histone acetylation to mediate transcriptional regulation by EIN3. However, no direct interaction between EIN2-C and EIN3 has been detected. To determine how EIN2-C and EIN3 act together, we followed a synthetic approach and engineered a chimeric EIN2-C with EIN3 DNA-binding activity but lacking its transactivation activity (EIN2C-EIN3DB). The overexpression of EIN2C-EIN3DB in either wild-type or in the ethylene-insensitive mutant ein3-1 eil1-1 led to a partial constitutive ethylene response. Chromatin immunoprecipitation sequencing showed that EIN2C-EIN3DB has DNA-binding activity, indicating that EIN3DB is functional in EIN2C-EIN3DB. Furthermore, native EIN3 protein levels determine EIN2C-EIN3DB binding activity and binding targets in a positive feedback loop by interacting with EIN2C-EIN3DB to form a heterodimer. Additionally, although EIN3 does not direct affect histone acetylation levels in the absence of EIN2, it is required for the ethylene-induced elevation of H3K14Ac and H3K23Ac in the presence of EIN2. Together, we reveal efficient and specific DNA-binding by dimerized EIN3 in the presence of ethylene to mediate positive feedback regulation, which is required for EIN2-directed elevation of histone acetylation to integrate into an EIN3-dependent transcriptional activation.
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