ArticleThe Plant cell2021
Interdependent evolution of biosynthetic gene clusters for momilactone production in rice.
Article in The Plant cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 61 citations in OpenAlex.
- Divergent roles of ent-kaurene oxidase paralogs in rice momilactone biosynthesis.Journal of integrative plant biology · 2026Article
- Cytochrome P450- and Dehydrogenase-Mediated Regiospecific and Stereoselective Formation of β- and γ-Lactones in Drimane-Type Sesquiterpenoid Biosynthesis.Journal of the American Chemical Society · 2026Article
- A Review of Plant-Derived Diterpenoid Biosynthesis: From Structural Scaffold Diversity and Lineage-Associated Distribution to Enzyme Mining and Discovery Strategies.Molecules (Basel, Switzerland) · 2026Review
- Transcriptomic profiling reveals stage-specific responses to cold stress in rice seedlings.BMC plant biology · 2026Article
- An Ustilaginoidea virens Nuclear Effector SCRE7 Inhibits Rice Immunity via Suppressing OsLBD11/12-Promoted Transcription of OsCPS2.Plant biotechnology journal · 2026Article
- Single-Cell and Spatial Transcriptomics Reveals a Stereoscopic Response of Rice Leaf Cells to Magnaporthe oryzae Infection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Evolution and diversification of the momilactone biosynthetic gene cluster in the genus Oryza.The New phytologist · 2025Article
- Metabolomic Analysis Reveals the Diversity of Defense Metabolites in Nine Cereal Crops.Plants (Basel, Switzerland) · 2025Article
- Large-scale genomic deletion inFrontiers in plant science · 2025Article
- OsbHLH5 Synergically Regulates Phenolamide and Diterpenoid Phytoalexins Involved in the Defense of Rice Against Pathogens.International journal of molecular sciences · 2024Article
- Discovery of bifunctional diterpene cyclases/synthases in bacteria supports a bacterial origin for the plant terpene synthase gene family.Horticulture research · 2024Article
- Enhancing Crop Resilience: Insights from Labdane-Related Diterpenoid Phytoalexin Research in Rice (Current issues in molecular biology · 2024Review
- The Diterpene Isopimaric Acid Modulates the Phytohormone Pathway to PromoteCurrent issues in molecular biology · 2024Article
- The gradual establishment of complex coumarin biosynthetic pathway in Apiaceae.Nature communications · 2024Article
- Genome-Wide Identification and Expression Analysis ofInternational journal of molecular sciences · 2024Article
- Chemically Mediated Plant-Plant Interactions: Allelopathy and Allelobiosis.Plants (Basel, Switzerland) · 2024Review
- Defensive Molecules Momilactones A and B: Function, Biosynthesis, Induction and Occurrence.Toxins · 2023Review
- Article
- Plant (di)terpenoid evolution: from pigments to hormones and beyond.Natural product reports · 2023Review
- Uncovering a miltiradiene biosynthetic gene cluster in the Lamiaceae reveals a dynamic evolutionary trajectory.Nature communications · 2023Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Plants can contain biosynthetic gene clusters (BGCs) that nominally resemble those found in microbes. However, while horizontal gene transmission is often observed in microbes, plants are limited to vertical gene transmission, implying that their BGCs may exhibit distinct inheritance patterns. Rice (Oryza sativa) contains two unlinked BGCs involved in diterpenoid phytoalexin metabolism, with one clearly required for momilactone biosynthesis, while the other is associated with production of phytocassanes. Here, in the process of elucidating momilactone biosynthesis, genetic evidence was found demonstrating a role for a cytochrome P450 (CYP) from the other "phytocassane" BGC. This CYP76M8 acts after the CYP99A2/3 from the "momilactone" BGC, producing a hemiacetal intermediate that is oxidized to the eponymous lactone by a short-chain alcohol dehydrogenase also from this BGC. Thus, the "momilactone" BGC is not only incomplete, but also fractured by the need for CYP76M8 to act in between steps catalyzed by enzymes from this BGC. Moreover, as supported by similar activity observed with orthologs from the momilactone-producing wild-rice species Oryza punctata, the presence of CYP76M8 in the other "phytocassane" BGC indicates interdependent evolution of these two BGCs, highlighting the distinct nature of BGC assembly in plants.
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