ArticlePLoS pathogens2021
Effector and regulator: Diverse functions of C. elegans C-type lectin-like domain proteins.
Article in PLoS pathogens, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
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- Genetic Control of Gut Microbial Diversity Enhances Host Resistance to Pathogenic Infections inMicroorganisms · 2026Article
- Transcriptomic insights into the healthspan-enhancing effects of C. chinensis seed and E. ulmoides bark extracts in Caenorhabditis elegans.Biogerontology · 2025Article
- RiboTRAP-seq identifies spatially distinct functions for the anterior and posterior intestine in immune and metabolic regulation inbioRxiv : the preprint server for biology · 2025Article
- Enhanced Longevity and Immunity inFood science of animal resources · 2025Article
- Genes linked to schistosome resistance identified in a genome-wide association study of African snail vectors.Nature communications · 2025Article
- Identification of intestinal mediators ofmBio · 2025Article
- Use ofBiomolecules · 2024Review
- The cysteine-rich virulence factor NipA of Arthrobotrys flagrans interferes with cuticle integrity of Caenorhabditis elegans.Nature communications · 2024Article
- Metabolic Regulation of Longevity and Immune Response inJournal of microbiology and biotechnology · 2024Article
- The matrisome landscape controlling in vivo germ cell fates.Nature communications · 2024Article
- ThemBio · 2024Article
- An organismal understanding of C. elegans innate immune responses, from pathogen recognition to multigenerational resistance.Seminars in cell & developmental biology · 2024Review
- The intricate triangular interaction between protective microbe, pathogen and host determines fitness of the metaorganism.Proceedings. Biological sciences · 2023Article
- Host and microbiome jointly contribute to environmental adaptation.The ISME journal · 2023Article
- TDP-1 and FUST-1 co-inhibit exon inclusion and control fertility together with transcriptional regulation.Nucleic acids research · 2023Article
- TDP-1 and FUST-1 co-inhibit exon inclusion and control fertility together with transcriptional regulation.bioRxiv : the preprint server for biology · 2023Article
- Investigation of Diagnostic and Prognostic Value of CLEC4M of Non-Small Cell Lung Carcinoma Associated with Immune Microenvironment.International journal of general medicine · 2023Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
In C. elegans, 283 clec genes encode a highly diverse family of C-type lectin-like domain (CTLD) proteins. Since vertebrate CTLD proteins have characterized functions in defense responses against pathogens and since expression of C. elegans clec genes is pathogen-dependent, it is generally assumed that clec genes function in C. elegans immune defenses. However, little is known about the relative contribution and exact function of CLEC proteins in C. elegans immunity. Here, we focused on the C. elegans clec gene clec-4, whose expression is highly upregulated by pathogen infection, and its paralogs clec-41 and clec-42. We found that, while mutation of clec-4 resulted in enhanced resistance to the Gram-positive pathogen Bacillus thuringiensis MYBt18247 (Bt247), inactivation of clec-41 and clec-42 by RNAi enhanced susceptibility to Bt247. Further analyses revealed that enhanced resistance of clec-4 mutants to Bt247 was due to an increase in feeding cessation on the pathogen and consequently a decrease in pathogen load. Moreover, clec-4 mutants exhibited feeding deficits also on non-pathogenic bacteria that were in part reflected in the clec-4 gene expression profile, which overlapped with gene sets affected by starvation or mutation in nutrient sensing pathways. However, loss of CLEC-4 function only mildly affected life-history traits such as fertility, indicating that clec-4 mutants are not subjected to dietary restriction. While CLEC-4 function appears to be associated with the regulation of feeding behavior, we show that CLEC-41 and CLEC-42 proteins likely function as bona fide immune effector proteins that have bacterial binding and antimicrobial capacities. Together, our results exemplify functional diversification within clec gene paralogs.
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