SynthesisPloS one2021
Efficacy, safety and complications of autologous fat grafting to the eyelids and periorbital area: A systematic review and meta-analysis.
Synthesis in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Fat Necrosis After Facial Autologous Fat Grafting: A Systematic Review of Reported Complications and Management Strategies.Aesthetic plastic surgery · 2026Pooled it
- Seven Years of Complaints from Patients in Plastic Surgery Hospitals About Autologous Fat Transfer Procedures.Aesthetic plastic surgery · 2026Article
- Abdominal fat graft migration into bulbar subconjunctival space after midface fat transfer: a case report.Orbit (Amsterdam, Netherlands) · 2026Article
- Objective Assessment of Combined Orbital Fat Repositioning and Fat Grafting in Upper Eyelid Hollowing.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2026Article
- Article
- Facial Injectable Fillers in Aesthetic Medicine: Clinical Applications and Safety Strategies.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Applications of Magnetic Resonance Imaging in Upper Eyelid Anatomy and Upper Eyelid Blepharoplasty: A Systematic Review.Plastic and reconstructive surgery. Global open · 2025Article
- Article
- Correction of Infraorbital Dark Circles Using Autologous Adipose-Derived Collagen Filler: A Novel Regenerative Option.Aesthetic plastic surgery · 2024Article
- Fat or fillers: The dilemma in eyelid surgery.World journal of clinical cases · 2024Review
- Letter in reply to Letter to the Editor: Fat injection as a valuable tool for lower eyelid retraction management: a retrospective, observational, single blind, case-control study.Aesthetic plastic surgery · 2023Article
- Correction of Mild-to-Moderate Sunken Upper Eyelids of Asians with Stromal Vascular Fraction Gel.Ophthalmology and therapy · 2023Article
- The Postsurgical Clavien-Dindo Classification in Minor Surgery Can Improve Perception and Communication (Investigation on Blepharoplasty).Journal of personalized medicine · 2022Article
- Clinical evaluation of corrective effect of infraorbital depression by fat granule auto-transplantation via oral mucosa incision.Annals of translational medicine · 2022Article
- Nanofat: A therapeutic paradigm in regenerative medicine.World journal of stem cells · 2021Review
- Combined supraperiosteal microfat grafting and intradermal nanofat for the treatment of periorbital melanosis (dark circles).Journal of cutaneous and aesthetic surgeryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn recent years, autologous fat grafting (AFG), also known as fat transfer or lipofilling, has been widely performed for periorbital rejuvenation and defect correction, although the evidence regarding its efficacy and safety is still lacking. Besides, with respect to the periorbital region, it is invariably the earliest appearance area of the facial aging phenomenon. Therefore, a systematic review and meta-analysis is needed to evaluate the efficacy and safety of this technique.
methodsA literature search was performed in PubMed, Embase, and the Cochrane library databases on November 20, 2020, adhering to the PRISMA guidelines, to identify all relevant articles. Then, a data extraction and standardization process was performed to assess all outcome data. Ultimately, the data were assessed using a random effects regression model with comprehensive meta-analysis software.
resultsThirty-nine studies consisting of 3 cohorts and 36 case series with a total of 4046 cases were included. Meta-analysis revealed a relatively high satisfaction rate of 90.9% (95% CI, 86.4%-94.0%). Frequent complications in 4046 patients receiving AFG were edema, chemosis, and contour irregularity, with an overall complication rate of 7.9% (95% CI, 4.8%-12.8%).
conclusionThis systematic review and meta-analysis showed that AFG for rejuvenation of eyelids and periorbital area provided a high satisfaction rate and did not result in severe complications. Therefore, AFG might be performed safely for periorbital rejuvenation and reconstruction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.