ArticlePloS one2021
Seroprevalence of hospital staff in a province with zero COVID-19 cases.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Polymerase chain reaction-positivity and predictors for SARS-CoV-2 infection among diagnosed cases' in North West Ethiopia.Health science reports · 2023Article
- Monitoring the COVID-19 immune landscape in Japan.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Article
- Seroprevalence of SARS-CoV-2 on health professionals via Bayesian estimation: a Brazilian case study before and after vaccines.Acta tropica · 2022Article
- [Reply to "Effectiveness of mRNA Covid-19 vaccine in healthcare workers"].Enfermedades infecciosas y microbiologia clinica · 2022Article
- [Reply to "Effectiveness of mRNA Covid-19 vaccine in healthcare workers"].Enfermedades infecciosas y microbiologia clinica (English ed.) · 2022Article
- Effectiveness of mRNA Covid-19 vaccine in healthcare workers.Enfermedades infecciosas y microbiologia clinica · 2022Article
- Clinical Manifestations, Imaging Procedures and Laboratory Parameters among Hospitalized Patients with COVID-19 in Ilam Province, Western Iran.Ethiopian journal of health sciences · 2022Article
- Effectiveness of mRNA Covid-19 vaccine in healthcare workers.Enfermedades infecciosas y microbiologia clinica (English ed.) · 2022Article
- SARS-CoV-2 Cross-Reactivity in Prepandemic Serum from Rural Malaria-Infected Persons, Cambodia.Emerging infectious diseases · 2022Article
- Immunogenicity of ChAdOx1 nCoV-19 Booster Vaccination Following Two CoronaVac Shots in Healthcare Workers.Vaccines · 2022Article
- Observational
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 ) IgG-antibody seroprevalence among quarantined population, during the first wave of COVID-19 pandemic, In North West Ethiopia (from 30 April to 30 May 2020).SAGE open medicine · 2022Article
- SerumCovid database: Description and preliminary analysis of serological COVID-19 diagnosis in healthcare workers.PloS one · 2022Article
- COVID-19 seroprevalence among hospital staff and preprocedural patients in Thai community hospitals: a cross-sectional study.BMJ open · 2021Article
- Pre-pandemic SARS-CoV-2 serological reactivity in rural malaria-experienced Cambodians.medRxiv : the preprint server for health sciences · 2021Article
- Did Laos really control the transmission of SARS-CoV-2 in 2020?The Lancet regional health. Western Pacific · 2021Article
- Low seroprevalence of COVID-19 in Lao PDR, late 2020.The Lancet regional health. Western Pacific · 2021Article
- Tracking COVID-19 with wastewater to understand asymptomatic transmission.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Article
- Regular testing of asymptomatic healthcare workers identifies cost-efficient SARS-CoV-2 preventive measures.PloS one · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCOVID-19 seroprevalence data, particularly in less developed countries with a relatively low incidence, has been scant. We aimed to explore the seroprevalence of hospital staff in the area with zero confirmed COVID-19 case to shed light on the situation of COVID-19 infection in zero or low infection rate countries where mass screening was not readily available.
methodsA locally developed rapid immunoglobulin M (IgM)/immunoglobulin G (IgG) test kit was used for hospital staff screening of Ranong hospital which is located in a province with zero COVID-19 prevalence in Thailand from 17th April to 17th May 2020. All staff was tested, 100 of which were randomly invited to have a repeating antibody test in one month. (Thai Clinical Trials Registry: TCTR20200426002).
resultsOf 844 hospital staff, 82 were tested twice one month apart (response rate for repeating antibody test 82%). Overall, 0.8% of the participants (7 of 844) had positive IgM, none had positive IgG. Female staff had 1.0% positive IgM (95% CI: 0.5-2.1%) while male had 0.5% positive IgM (95% CI: 0.1-2.6%). No participants with a history of travel to the high-risk area or close contact with PCR-confirmed COVID-19 case developed SARS-CoV-2 antibodies. Among 844 staff, 811 had no symptoms and six of them developed IgM seropositive (0.7%) while 33 had minor symptoms and only one of them developed IgM seropositive (3.0%). No association between SARS-CoV-2 IgM status and gender, history of travel to a high-risk area, close contact with PCR-confirmed or suspected COVID-19 case, presence of symptoms within 14 days, or previous PCR status was found. None of the hospital staff developed SARS-CoV-2 IgG.
conclusionsCOVID-19 antibody test could detect a considerable number of hospital staff who could be potential silent spreaders in a province with zero COVID-19 cases. Accurate antibody testing is a valuable screening tool, particularly in asymptomatic healthcare workers. Trial registration: This study was approved by the Institutional Review Board of Chulalongkorn University (IRB No.236/63) and the Institutional Review Board of Ranong Hospital. (Thai Clinical Trials Registry: TCTR20200426002).
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