Evidence map›Paper›PMID 33793363›Full record

ArticleThe American journal of sports medicine2021

The Clinical Radiographic Incidence of Posttraumatic Osteoarthritis 10 Years After Anterior Cruciate Ligament Reconstruction: Data From the MOON Nested Cohort.

MOON Group, Josh S Everhart, Morgan H Jones, Sercan Yalcin, Emily K Reinke, Laura J Huston, Jack T Andrish, Charles L Cox, David C Flanigan, Christopher C Kaeding and 7 more

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of sports medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02717559 (Multicenter Orthopaedic Outcomes Network), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02717559 completednot on this map

Multicenter Orthopaedic Outcomes Network (MOON) ACL Reconstruction (ACLR): 10 Year Onsite Follow-up

TypeobservationalSponsorVanderbilt University Medical CenterRan2016 to 2025Enrolled225ConditionsOsteoarthritis, Arthritis, Joint Diseases, Musculoskeletal Diseases
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  11. Anterior Cruciate Ligament Tears among Football Players.Current reviews in musculoskeletal medicine · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

MOON GroupInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA.
Josh S EverhartInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA.
Morgan H JonesInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA.
Sercan YalcinInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA.
Emily K ReinkeInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA.
Laura J HustonInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA.
Jack T AndrishInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA.
Charles L CoxInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA.
David C FlaniganInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA.
Christopher C KaedingInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA.
Robert A MagnussenInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA.
Nancy ObuchowskiInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA.
Richard D ParkerInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA.
Angela D PedrozaInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA.
Rosemary A SandersInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA.
Carl S WinalskiInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA.
Kurt P SpindlerInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA.

Funding

Prognosis and Predictors of ACL Reconstruction: A Multicenter Cohort StudyR01AR053684 · NIAMS · VANDERBILT UNIVERSITY · PI SPINDLER, KURT PAUL · 2006 to 2020
$8.3M
NIAMS NIH HHS R01 AR053684
6 · The paper itself

Abstract

backgroundThe incidence of posttraumatic osteoarthritis (PTOA) based on clinical radiographic grading criteria at 10 years after anterior cruciate ligament (ACL) reconstruction (ACLR) has not been well-defined in a prospective cohort of young athletic patients. HYPOTHESIS: Among young athletic patients, there is a high incidence of clinical radiographic PTOA at 10 years after ACLR. Additionally, there is a significant difference in clinical radiographic osteoarthritis (OA) changes (joint space narrowing and osteophyte formation) between ACL-reconstructed and contralateral knees at 10 years. STUDY

designCase series; Level of evidence, 4.

methodsThe first 146 patients in an ongoing nested cohort study of the Multicenter Orthopaedic Outcomes Network (MOON) prospective cohort presented for a minimum 10-year follow-up. Included patients had a sports-related ACL injury, were aged <33 years at the time of ACLR, had no history of ipsilateral or contralateral knee surgery, and did not undergo revision ACLR before follow-up. Bilateral knee metatarsophalangeal view radiographs were obtained and graded according to International Knee Documentation Committee (IKDC), Osteoarthritis Research Society International (OARSI), and modified Kellgren-Lawrence (KL) criteria by 2 blinded reviewers. The incidence and severity of ipsilateral and contralateral radiographic OA were determined among patients without a contralateral ACL injury before 10-year follow-up (N = 133).

resultsInterrater reliability was substantial for the IKDC (Gwet Agreement Coefficient [AC] 1 = 0.71), moderate for the KL (0.48), and almost perfect for the OARSI (0.84) grading systems. Among patients with a contralateral radiographically normal knee, the 10-year incidence of clinical radiographic PTOA after ACLR was 37% as defined by osteophytes and 23% as defined by joint space narrowing. The maximum side-to-side difference in the OARSI osteophyte grade in the medial or lateral compartment was 0 in 65% of patients, 1 in 20%, and ≥2 in 15%. The maximum side-to-side difference in the OARSI joint space narrowing grade was 0 in 77% of patients, 1 in 19%, and ≥2 in 4%.

conclusionIn young active patients, the 10-year incidence of clinical radiographic PTOA after ACLR was 37% as defined by osteophytes and 23% as defined by joint space narrowing. The mean difference in the degree of osteophyte formation (≤1 grade in 85%) and joint space narrowing (≤1 grade in 96%) between the ACL-reconstructed and contralateral knees was small. REGISTRATION: NCT02717559 (ClinicalTrials.gov identifier).

Indexed as

Anterior Cruciate Ligament InjuriesAnterior Cruciate Ligament ReconstructionOrthopedicsOsteoarthritisOsteoarthritis, KneeAgedCohort StudiesHumansIncidenceKnee JointProspective StudiesReproducibility of ResultsACL reconstructionjoint space narrowingposttraumatic osteoarthritisradiographic osteoarthritisweightbearing radiographs

Identifiers

PMID33793363
PMCPMC8375261

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.