Evidence map›Paper›PMID 33793326›Full record

ReviewCirculation research2021

Guideline-Driven Management of Hypertension: An Evidence-Based Update.

Robert M Carey, Jackson T Wright, Sandra J Taler, Paul K Whelton

2 registry-linked trialsOpen access · bronzeAbstract readReview
In one paragraph

Review in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 103 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 5 pooled it
15.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05890274 nacompletednot on this mapstarted 2022, after this paper: background citation

Improving Outpatient Comprehensive Atrial Fibrillation Care Across Central North Carolina Through Direct Primary Care and Patient Engagement

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2022 to 2026Enrolled70ConditionsAtrial FibrillationArmsAF and EKG Interpretation Project ECHO
NCT07236125 recruitingnot on this mapstarted 2026, after this paper: background citation

Investigation of the Relationship Between Dietary Nitrate and Oral Microbiota in Children With Primary Hypertension

Typeobservational_patient_registrySponsorYelda KasımoğluRan2026 to 2027Enrolled48ConditionsPrimary HypertensionArmsNo active intervention
3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 5 syntheses or guidelines pooled it, 167 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
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  5. Pooled it
  6. Trial
  7. Application effects of information-based health management combined with knowledge-attitude-practice health education model in hypertensive patients.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026
    Trial
  8. Review
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  10. Observational
  11. Review
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  17. Review
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  20. Investigating feature-engineered predictors for systolic blood pressure changes in an mHealth-based disease management program.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Robert M CareyDepartment of Medicine, University of Virginia Health System, Charlottesville (R.M.C).
Jackson T WrightDepartment of Medicine, Case-Western Reserve University School of Medicine, Cleveland, OH (J.T.W.).
Sandra J TalerDepartment of Medicine, Mayo Clinic College of Medicine, Rochester, MN (S.J.T.).
Paul K WheltonDepartments of Epidemiology and Medicine, Tulane University, New Orleans, LA (P.K.W.).
Case Western Reserve University · USMayo Clinic · USTulane University · USUniversity of Virginia Health System · US

Funding

Spatiotemporal transregulation of D1-like angiotensin receptors in genetically...P01HL074940 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI JOSE, PEDRO A. · 2004 to 2020
$31.8M
Tulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Katherine Teresa Mills · 2016 to 2026
$25.3M
Renal AT2 Receptors in HypertensionR01HL128189 · NHLBI · UNIVERSITY OF VIRGINIA · PI KELLER, SUSANNA R · 2016 to 2024
$5.0M
Achieving Outstanding Cardiovascular Health Outcomes for All Ohioans: a Statewide Cardiovascular Health Collaborative (Cardio-OH)U18HS027944 · AHRQ · CASE WESTERN RESERVE UNIVERSITY · PI BOLEN, SHARI DANIELLE, CARON, ALEECE · 2021 to 2023
$4.1M
AHRQ HHS U18 HS027944NHLBI NIH HHS P01 HL074940NHLBI NIH HHS R01 HL128189NIGMS NIH HHS P20 GM109036
6 · The paper itself

Abstract

Several important findings bearing on the prevention, detection, and management of hypertension have been reported since publication of the 2017 American College of Cardiology/American Heart Association Blood Pressure Guideline. This review summarizes and places in context the results of relevant observational studies, randomized clinical trials, and meta-analyses published between January 2018 and March 2021. Topics covered include blood pressure measurement, patient evaluation for secondary hypertension, cardiovascular disease risk assessment and blood pressure threshold for drug therapy, lifestyle and pharmacological management, treatment target blood pressure goal, management of hypertension in older adults, diabetes, chronic kidney disease, resistant hypertension, and optimization of care using patient, provider, and health system approaches. Presenting new information in each of these areas has the potential to increase hypertension awareness, treatment, and control which remain essential for the prevention of cardiovascular disease and mortality in the future.

Indexed as

HypertensionAgedAge FactorsAntihypertensive AgentsBlood PressureBlood Pressure DeterminationDiabetes MellitusDrug ResistanceHeart Disease Risk FactorsHumansHyperaldosteronismHypertension, RenovascularLife StyleMeta-Analysis as TopicObservational Studies as TopicPractice Guidelines as TopicAntihypertensive AgentsAmerican Heart Associationantihypertensive agentsblood pressurecardiovascular diseasehypertensionmortality

Identifiers

PMID33793326
PMCPMC8034801
OpenAlexW3142261265

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.