ArticleCirculation2021
Increased Reactive Oxygen Species-Mediated Ca
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Article in Circulation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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58citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
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Who cites it
58 citing papers in PubMed, 78 citations in OpenAlex.
- Peroxisomal catalase and plasmalogen biosynthesis protect from oxidative stress in Barth syndrome cardiomyopathy.Basic research in cardiology · 2026Article
- Stable Isotope-Resolved Metabolomics in Elucidating Mitochondrial Metabolic Reprogramming and Therapeutic Targets.Biomedical chromatography : BMC · 2026Review
- Exploring the role of CaMKII in exercise-induced cardioprotection.Human cell · 2026Review
- Shengmai San Ameliorates High-Glucose-Induced Calcium Homeostasis Imbalance via Improving Energy Metabolism in Neonatal Rat Cardiomyocytes.Pharmaceuticals (Basel, Switzerland) · 2026Article
- The interaction between sarcoplasmic reticulum and mitochondria: a novel mechanism for cardiac arrhythmia.Frontiers in physiology · 2026Review
- Bioenergetic and metabolic aberrations in induced pluripotent stem cell-derived cardiomyocytes generated from a patient with Wolff-Parkinson-White syndrome caused aFrontiers in cardiovascular medicine · 2026Article
- Synergistic antiarrhythmic mechanism of IJournal of translational medicine · 2025Article
- Defective vascular smooth muscle cell tafazzin impairs mitochondrial function and promotes atherosclerosis in preclinical models.Nature communications · 2025Article
- Modeling rare genetic disease with gene-edited induced pluripotent stem cells: relevance of the starting stock line.Stem cells translational medicine · 2025Article
- Optimization of gene knockout approaches and sgRNA selection in hPSCs with inducible Cas9 expression.Scientific reports · 2025Article
- Metabolic cardiomyopathies: untangling clinical heterogeneity with human stem-cell derived models.EMBO molecular medicine · 2025Review
- Roles of Autophagy and Oxidative Stress in Cardiovascular Disease.Antioxidants (Basel, Switzerland) · 2025Review
- Mechano-energetic uncoupling in heart failure.Nature reviews. Cardiology · 2025Review
- Mitochondria-Homing Drug Mitochonic Acid 5 Improves Barth Syndrome Myopathy in a Human-Induced Pluripotent Stem Cell Model and Barth Syndrome Drosophila Model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Virally delivered CMYA5 enhances the assembly of cardiac dyads.Nature biomedical engineering · 2025Article
- Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathy.Nature communications · 2025Article
- Modulation of mitochondrial voltage dependent anion channel: studies on bilayer electrophysiology.Frontiers in physiology · 2025Review
- A novelFrontiers in pediatrics · 2025Article
- What can ATP content tell us about Barth syndrome muscle phenotypes?Journal of translational genetics and genomics · 2025Article
- ECG Findings Are Poor Predictors for Adverse Events and Cardiac Death in Barth Syndrome.Progress in pediatric cardiology · 2024Article
Corrections and comments
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Authors and funding
19 authors at 7 institutions in 3 countries.
Xujie LiuDepartment of Cardiology, Boston Children's Hospital, MA (X.L., S.W., X.G., R.O., F.L., M.P., S.d.l.S.B., Q.M., G.W., J.C., Y.G., V.J.B., W.T.P.).
Suya WangDepartment of Cardiology, Boston Children's Hospital, MA (X.L., S.W., X.G., R.O., F.L., M.P., S.d.l.S.B., Q.M., G.W., J.C., Y.G., V.J.B., W.T.P.).
Xiaoling GuoDepartment of Cardiology, Boston Children's Hospital, MA (X.L., S.W., X.G., R.O., F.L., M.P., S.d.l.S.B., Q.M., G.W., J.C., Y.G., V.J.B., W.T.P.).
Yifei LiKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu (Y.L.).
Roza OgurluDepartment of Cardiology, Boston Children's Hospital, MA (X.L., S.W., X.G., R.O., F.L., M.P., S.d.l.S.B., Q.M., G.W., J.C., Y.G., V.J.B., W.T.P.).
Fujian LuDepartment of Cardiology, Boston Children's Hospital, MA (X.L., S.W., X.G., R.O., F.L., M.P., S.d.l.S.B., Q.M., G.W., J.C., Y.G., V.J.B., W.T.P.).
Maksymilian ProndzynskiDepartment of Cardiology, Boston Children's Hospital, MA (X.L., S.W., X.G., R.O., F.L., M.P., S.d.l.S.B., Q.M., G.W., J.C., Y.G., V.J.B., W.T.P.).
Sofia de la Serna BuzonDepartment of Cardiology, Boston Children's Hospital, MA (X.L., S.W., X.G., R.O., F.L., M.P., S.d.l.S.B., Q.M., G.W., J.C., Y.G., V.J.B., W.T.P.).
Qing MaDepartment of Cardiology, Boston Children's Hospital, MA (X.L., S.W., X.G., R.O., F.L., M.P., S.d.l.S.B., Q.M., G.W., J.C., Y.G., V.J.B., W.T.P.).
Donghui ZhangState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Science, Hubei University, Wuhan, China (D.Z.).
Gang WangDepartment of Cardiology, Boston Children's Hospital, MA (X.L., S.W., X.G., R.O., F.L., M.P., S.d.l.S.B., Q.M., G.W., J.C., Y.G., V.J.B., W.T.P.).
Justin CottonDepartment of Cardiology, Boston Children's Hospital, MA (X.L., S.W., X.G., R.O., F.L., M.P., S.d.l.S.B., Q.M., G.W., J.C., Y.G., V.J.B., W.T.P.).
Yuxuan GuoDepartment of Cardiology, Boston Children's Hospital, MA (X.L., S.W., X.G., R.O., F.L., M.P., S.d.l.S.B., Q.M., G.W., J.C., Y.G., V.J.B., W.T.P.).
Ling XiaoDepartment of Cardiology, Massachusetts General Hospital, Boston (L.X., D.J.M.).
David J MilanDepartment of Cardiology, Massachusetts General Hospital, Boston (L.X., D.J.M.).
Yang XuDepartment of Anesthesiology, New York University School of Medicine (Y.X., M.S.).
Michael SchlameDepartment of Anesthesiology, New York University School of Medicine (Y.X., M.S.).
Vassilios J BezzeridesDepartment of Cardiology, Boston Children's Hospital, MA (X.L., S.W., X.G., R.O., F.L., M.P., S.d.l.S.B., Q.M., G.W., J.C., Y.G., V.J.B., W.T.P.).
William T PuDepartment of Cardiology, Boston Children's Hospital, MA (X.L., S.W., X.G., R.O., F.L., M.P., S.d.l.S.B., Q.M., G.W., J.C., Y.G., V.J.B., W.T.P.).
Children's Research Hospital · JPMassachusetts General Hospital · USNew York University · USHarvard College Observatory · USHubei University · CNSichuan University · CNWenzhou Medical University · CN
Funding
Aberrant Cardiolipin Dynamics in Barth Syndrome - Renewal - 1R01GM115593 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SCHLAME, MICHAEL · 2015 to 2023
$2.9MMulti-scale modeling of inherited pediatric cardiomyopathiesUG3HL141798 · NHLBI · HARVARD UNIVERSITY · PI PARKER, KEVIN KIT, PU, WILLIAM TSWENCHING · 2017 to 2018
$2.6MUnderstanding mitochondrial regulation of cardiac development and function through studies of Barth SyndromeR01HL128694 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI PU, WILLIAM TSWENCHING · 2015 to 2018
$2.0MNovel molecular therapies for CPVTK08HL140197 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI BEZZERIDES, VASSILIOS JAMES · 2018 to 2022
$851kNHLBI NIH HHS K08 HL140197NHLBI NIH HHS R01 HL128694NHLBI NIH HHS UG3 HL141798NIGMS NIH HHS R01 GM115593
Abstract
backgroundMutations in tafazzin (
methodsWe performed in vivo electrophysiology to define arrhythmia vulnerability in cardiac-specific
resultsA subset of mice with cardiac-specific
conclusionsThis study identified a molecular pathway that links
Indexed as
AnimalsBarth SyndromeCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2HumansMiceMice, KnockoutReactive Oxygen SpeciesCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Reactive Oxygen SpeciesBarth syndromeCa2+ handlingcalcium-calmodulin-dependent protein kinase type 2induced pluripotent stem cellsreactive oxygen speciesryanodine receptor calcium release channel
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.