Evidence map›Paper›PMID 33793300›Full record

ArticleEnvironmental health perspectives2021

Bias due to Selection on Live Births in Studies of Environmental Exposures during Pregnancy: A Simulation Study.

Michael Leung, Marianthi-Anna Kioumourtzoglou, Raanan Raz, Marc G Weisskopf

Abstract read
In one paragraph

Article in Environmental health perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  19. A novel approach for inferring effects on pregnancy loss.American journal of epidemiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael LeungDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Marianthi-Anna KioumourtzoglouDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York City, New York, USA.
Raanan RazBraun School of Public Health and Community Medicine, Hebrew University of Jerusalem - Hadassah, Jerusalem, Israel.
Marc G WeisskopfDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
Air Pollution and Autism in Israel: A Population-Wide StudyR21ES026900 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI WEISSKOPF, MARC G · 2016 to 2017
$391k
NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R21 ES026900
6 · The paper itself

Abstract

backgroundStudies of the effects of prenatal environmental exposures on postnatal outcomes are particularly vulnerable to live birth bias; i.e., the bias that arises from the necessary restriction of the analysis to live births when that is influenced by both the exposure under study

objectivesIn the context of a recent publication of nitrogen dioxide (

methodsWe simulated the magnitude of bias under two selection mechanisms and when both mechanisms co-occur, assuming a true null effect. Simulation input parameters were based on characteristics of the original study and a range of plausible values for the prevalence of unmeasured factor

resultsWe found that the magnitude of bias was small when DISCUSSION: Our simulations illustrate that live birth bias may lead to exposure-outcome associations that are biased downward, where the extent of the bias depends on the fetal selection mechanism, the strength of that selection, and the prevalence of

Indexed as

Air PollutantsAutism Spectrum DisorderBiasEnvironmental ExposureFemaleHumansLive BirthNitrogen DioxidePregnancyAir PollutantsNitrogen Dioxide

Identifiers

PMID33793300
PMCPMC8043129

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.