Evidence map›Paper›PMID 33793228›Full record

ArticleChemical research in toxicology2021

Biomonitoring of Ambient Outdoor Air Pollutant Exposure in Humans Using Targeted Serum Albumin Adductomics.

Joshua W Smith, Robert N O'Meally, Derek K Ng, Jian-Guo Chen, Thomas W Kensler, Robert N Cole, John D Groopman

Open access · greenAbstract read
In one paragraph

Article in Chemical research in toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  7. Quo vadis blood protein adductomics?Archives of toxicology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Joshua W SmithDepartment of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, United States.ORCID 0000-0002-8636-8097
Robert N O'MeallyDepartment of Biological Chemistry, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, United States.
Derek K NgDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, United States.
Jian-Guo ChenQidong Liver Cancer Institute, Qidong, Jiangsu 226200, China.
Thomas W KenslerDepartment of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, United States.ORCID 0000-0002-6676-261X
Robert N ColeDepartment of Biological Chemistry, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, United States.
John D GroopmanDepartment of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, United States.
Johns Hopkins University · USQidong Liver Cancer Prevention Research · CN

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN KEITH MEEKER · 1985 to 2026
$208.6M
Targeting Nrf2 for Cancer ChemopreventionR35CA197222 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KENSLER, THOMAS W · 2015 to 2021
$6.7M
Detoxication of Air Pollutants in Humans with a Broccoli SupplementR01CA190610 · NCI · JOHNS HOPKINS UNIVERSITY · PI GROOPMAN, JOHN D · 2015 to 2019
$2.1M
Tracking 30 years of air pollution: Targeted adductomics for cancer preventionR21CA239154 · NCI · JOHNS HOPKINS UNIVERSITY · PI COLE, ROBERT N, GROOPMAN, JOHN D · 2020 to 2021
$421k
NCI NIH HHS P30 CA006973NCI NIH HHS R01 CA190610NCI NIH HHS R21 CA239154NCI NIH HHS R35 CA197222
6 · The paper itself

Abstract

Outdoor air pollution, a spatially and temporally complex mixture, is a human carcinogen. However, ambient measurements may not reflect subject-level exposures, personal monitors do not assess internal dose, and spot assessments of urinary biomarkers may not recapitulate chronic exposures. Nucleophilic sites in serum albumin-particularly the free thiol at Cys

Indexed as

Biological MonitoringAir PollutantsCarcinogensHumansMolecular StructureSerum AlbuminAir PollutantsCarcinogensSerum Albumin

Identifiers

PMID33793228
PMCPMC8195033
OpenAlexW3139569105

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.