ArticleAnalytical chemistry2021
AC Insulator-Based Dielectrophoretic Focusing of Particles and Cells in an "Infinite" Microchannel.
Article in Analytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Periodic Flows in Microfluidics.Small (Weinheim an der Bergstrasse, Germany) · 2024Review
- Recent Advances in Dielectrophoretic Manipulation and Separation of Microparticles and Biological Cells.Biosensors · 2024Review
- Development of a DC-Biased AC-Stimulated Microfluidic Device for the Electrokinetic Separation of Bacterial and Yeast Cells.Biosensors · 2024Article
- Assessing the Discriminatory Capabilities of iEK Devices under DC and DC-Biased AC Stimulation Potentials.Micromachines · 2023Article
- Numerical modeling reveals improved organelle separation for dielectrophoretic ratchet migration.Electrophoresis · 2023Article
- Design of a Low-Frequency Dielectrophoresis-Based Arc Microfluidic Chip for Multigroup Cell Sorting.Micromachines · 2023Article
- Microfluidic Technology for the Isolation and Analysis of Exosomes.Micromachines · 2022Review
- Comparing machine learning and deep learning regression frameworks for accurate prediction of dielectrophoretic force.Scientific reports · 2022Article
- Protein Dielectrophoresis: A Tale of Two Clausius-Mossottis-Or Something Else?Micromachines · 2022Article
- The latest advances on nonlinear insulator-based electrokinetic microsystems under direct current and low-frequency alternating current fields: a review.Analytical and bioanalytical chemistry · 2022Review
- Particle trapping in electrically driven insulator-based microfluidics: Dielectrophoresis and induced-charge electrokinetics.Electrophoresis · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
It is often necessary to prefocus particles and cells into a tight stream for subsequent separation and/or analysis in microfluidic devices. A DC electric field has been widely used for particle and cell focusing in insulator-based dielectrophoretic (iDEP) microdevices, where a large field magnitude, a high constriction ratio, and/or a long microchannel are usually required to enhance the iDEP effect. We demonstrate, in this work, an AC iDEP focusing technique, which utilizes a low-frequency AC electric field to generate both an oscillatory electrokinetic flow of the particle/cell suspension and a field direction-independent dielectrophoretic force for particle/cell focusing in a virtually "infinite" microchannel. We also develop a theoretical analysis to evaluate this focusing in terms of the AC voltage frequency, amplitude, and particle size, which are each validated through both experimental demonstration and numerical simulation. The effectiveness of AC iDEP focusing increases with the second order of electric field magnitude, superior to DC iDEP focusing with only a first-order dependence. This feature and the "infinite" channel length together remove the necessity of large electric field and/or small constriction in DC iDEP focusing of small particles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.