Evidence map›Paper›PMID 33793064›Full record

ArticleEMBO molecular medicine2021

Antioxidant nanozyme counteracts HIV-1 by modulating intracellular redox potential.

Shalini Singh, Sourav Ghosh, Virender Kumar Pal, MohamedHusen Munshi, Pooja Shekar, Diwakar Tumkur Narasimha Murthy, Govindasamy Mugesh, Amit Singh

Open access · goldAbstract read
In one paragraph

Article in EMBO molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Shalini SinghDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
Sourav GhoshDepartment of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, India.
Virender Kumar PalDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
MohamedHusen MunshiCentre for Infectious Disease Research (CIDR), Indian Institute of Science, Bangalore, India.
Pooja ShekarBangalore Medical College and Research Institute, Bangalore, India.
Diwakar Tumkur Narasimha MurthyDepartment of Internal Medicine, Bangalore Medical College and Research Institute, Bangalore, India.
Govindasamy MugeshDepartment of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, India.ORCID 0000-0002-5389-5309
Amit SinghDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.ORCID 0000-0001-6761-1664
Indian Institute of Science Bangalore · INBangalore Medical College and Research Institute · IN

Funding

Wellcome Trust
6 · The paper itself

Abstract

Reactive oxygen species (ROS) regulates the replication of human immunodeficiency virus (HIV-1) during infection. However, the application of this knowledge to develop therapeutic strategies remained unsuccessful due to the harmful consequences of manipulating cellular antioxidant systems. Here, we show that vanadium pentoxide (V

Indexed as

HIV-1HIV InfectionsAntioxidantsCD4-Positive T-LymphocytesHumansOxidation-ReductionVirus LatencyAntioxidantsglutathioneglutathione peroxidaseHIVlatencynanozymes

Identifiers

PMID33793064
PMCPMC8103102
OpenAlexW3140806118

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.