Evidence map›Paper›PMID 33793010›Full record

ArticleDepression and anxiety2021

Neural correlates of emotional reactivity and regulation in youth with and without anxiety.

Namita Tanya Padgaonkar, Jessica Phuong Uy, Samantha DePasque, Adriana Galván, Tara S Peris

Abstract read
In one paragraph

Article in Depression and anxiety, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Linking Emotion Dysregulation to Autistic Traits Across Neurodiverse Samples.Autism : the international journal of research and practice · 2026
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  6. The roles of emotional responding and regulation in adolescent friendship stability: A multimethod functional magnetic resonance imaging study.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026
    Article
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  10. Practical, Economic, and Policy Implications of the Leve et al. Paper.Prevention science : the official journal of the Society for Prevention Research · 2024
    Article
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  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Namita Tanya PadgaonkarDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles (UCLA), Los Angeles, California, USA.ORCID 0000-0003-2543-0325
Jessica Phuong UyDepartment of Psychology, UCLA, Los Angeles, California, USA.
Samantha DePasqueDepartment of Psychology, UCLA, Los Angeles, California, USA.
Adriana GalvánDepartment of Psychology, UCLA, Los Angeles, California, USA.
Tara S PerisDivision of Child and Adolescent Psychiatry, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, California, USA.ORCID 0000-0003-3643-3994

Funding

Trajectories of Brain Maturation among Youth at Risk for AnxietyR01MH110476 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GALVAN, ADRIANA, PERIS, TARA S · 2017 to 2023
$4.1M
Doctoral Training in Brain and Behavioral Development During Adolescence (UCLA BBDA)T32HD091059 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Mirella Dapretto, ANDREW J FULIGNI · 2018 to 2026
$1.7M
Friends of SemelNational Institute of Child Health and Human Development 1T32HD091059National Science Foundation 1650604NICHD NIH HHS T32 HD091059NIMH NIH HHS R01 MH110476
6 · The paper itself

Abstract

backgroundYouth with anxiety disorders struggle with managing emotions relative to peers, but the neural basis of this difference has not been examined.

methodsYouth (M

resultsGroups did not differ on emotional reactivity or regulation. However, fronto-limbic activation after viewing aversive imagery with and without regulation, as well as affect ratings without regulation, were higher for anxious youth. Neither group demonstrated age-related changes in regulation, though anxious youth became less reactive with age. Stronger amygdala-ventromedial prefrontal cortex connectivity related to greater anxiety in control youth, but less anxiety in anxious youth.

conclusionAnxious youth regulated when instructed, but regulation ability did not relate to age. Viewing aversive imagery related to heightened fronto-limbic activation even after reappraisal. Emotion dysregulation in youth anxiety disorders may stem from heightened emotionality and potent bottom-up neurobiological responses to aversive stimuli. Findings suggest the importance of treatments focused on both reducing initial emotional reactivity and bolstering regulatory capacity.

Indexed as

AmygdalaAnxiety DisordersAdolescentAnxietyBrain MappingEmotionsHumansMagnetic Resonance ImagingPrefrontal Cortexanxietychildren & adolescentsemotion regulationfMRI

Identifiers

PMID33793010
PMCPMC8922214

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.