Evidence map›Paper›PMID 33792914›Full record

ArticleBiometrics2022

Testing for association in multiview network data.

Lucy L Gao, Daniela Witten, Jacob Bien

Abstract read
In one paragraph

Article in Biometrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lucy L GaoDepartment of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada.ORCID 0000-0002-6811-0746
Daniela WittenDepartments of Statistics and Biostatistics, University of Washington, Seattle, Washington, USA.
Jacob BienDepartment of Data Sciences and Operations, University of Southern California, Los Angeles, California, USA.

Funding

High-dimensional unsupervised learning, with applications to genomicsDP5OD009145 · OD · UNIVERSITY OF WASHINGTON · PI WITTEN, DANIELA · 2011 to 2015
$1.8M
A Modeling Framework for Multi-View Data, with Applications to the Pioneer 100 Study and Protein Interaction NetworksR01GM123993 · NIGMS · UNIVERSITY OF WASHINGTON · PI BIEN, JACOB, WITTEN, DANIELA · 2017 to 2020
$1.3M
NIGMS NIH HHS R01 GM123993NIH HHS DP5 OD009145
6 · The paper itself

Abstract

In this paper, we consider data consisting of multiple networks, each composed of a different edge set on a common set of nodes. Many models have been proposed for the analysis of such multiview network data under the assumption that the data views are closely related. In this paper, we provide tools for evaluating this assumption. In particular, we ask: given two networks that each follow a stochastic block model, is there an association between the latent community memberships of the nodes in the two networks? To answer this question, we extend the stochastic block model for a single network view to the two-view setting, and develop a new hypothesis test for the null hypothesis that the latent community memberships in the two data views are independent. We apply our test to protein-protein interaction data from the HINT database. We find evidence of a weak association between the latent community memberships of proteins defined with respect to binary interaction data and the latent community memberships of proteins defined with respect to cocomplex association data. We also extend this proposal to the setting of a network with node covariates. The proposed methods extend readily to three or more network/multivariate data views.

Indexed as

AlgorithmsProteinsProteinscommunity detectiondata integrationmultiview datanode covariatesstochastic block model

Identifiers

PMID33792914
PMCPMC8484362

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.