Evidence map›Paper›PMID 33792344›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2021

Low LAL (Lysosomal Acid Lipase) Expression by Smooth Muscle Cells Relative to Macrophages as a Mechanism for Arterial Foam Cell Formation.

Joshua A Dubland, Sima Allahverdian, Katrina J Besler, Carleena Ortega, Ying Wang, Collin S Pryma, Kamel Boukais, Teddy Chan, Michael A Seidman, Gordon A Francis

Open access · bronzeAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Long Non-Coding RNA Function in Smooth Muscle Cell Plasticity and Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Joshua A DublandDepartments of Medicine (J.A.D., S.A., K.J.B., C.O., C.S.P., K.B., T.C., G.A.F.), Centre for Heart Lung Innovation, Providence Healthcare Research Institute, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
Sima AllahverdianDepartments of Medicine (J.A.D., S.A., K.J.B., C.O., C.S.P., K.B., T.C., G.A.F.), Centre for Heart Lung Innovation, Providence Healthcare Research Institute, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
Katrina J BeslerDepartments of Medicine (J.A.D., S.A., K.J.B., C.O., C.S.P., K.B., T.C., G.A.F.), Centre for Heart Lung Innovation, Providence Healthcare Research Institute, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
Carleena OrtegaDepartments of Medicine (J.A.D., S.A., K.J.B., C.O., C.S.P., K.B., T.C., G.A.F.), Centre for Heart Lung Innovation, Providence Healthcare Research Institute, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
Ying WangPathology and Laboratory Medicine (Y.W.), Centre for Heart Lung Innovation, Providence Healthcare Research Institute, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
Collin S PrymaDepartments of Medicine (J.A.D., S.A., K.J.B., C.O., C.S.P., K.B., T.C., G.A.F.), Centre for Heart Lung Innovation, Providence Healthcare Research Institute, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
Kamel BoukaisDepartments of Medicine (J.A.D., S.A., K.J.B., C.O., C.S.P., K.B., T.C., G.A.F.), Centre for Heart Lung Innovation, Providence Healthcare Research Institute, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
Teddy ChanDepartments of Medicine (J.A.D., S.A., K.J.B., C.O., C.S.P., K.B., T.C., G.A.F.), Centre for Heart Lung Innovation, Providence Healthcare Research Institute, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
Michael A SeidmanLaboratory Medicine and Pathobiology, University of Toronto, Canada (M.A.S.).
Gordon A FrancisDepartments of Medicine (J.A.D., S.A., K.J.B., C.O., C.S.P., K.B., T.C., G.A.F.), Centre for Heart Lung Innovation, Providence Healthcare Research Institute, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
St. Paul's Hospital · CASt. Paul's Hospital · CASt. Michael's Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

[Figure: see text].

Indexed as

AnimalsAortaAtherosclerosisCholesterolDisease Models, AnimalFoam CellsHumansMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, Knockout, ApoEMuscle, Smooth, VascularMyocytes, Smooth MuscleRAW 264.7 CellsSterol EsteraseCholesterolLIPA protein, humanlysosomal acid lipase, mouseSterol Esteraseatherosclerosischolesterolfoam cellsmacrophagesmyocytessmooth muscle

Identifiers

PMID33792344
OpenAlexW3146375440

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.