ArticleAPMIS : acta pathologica, microbiologica, et immunologica Scandinavica2021
Reduced frequency of T helper 17 and T helper 1 cells and their association with critical coronavirus disease 2019.
Article in APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 9 citations in OpenAlex.
- Flow cytometry profiling of cellular immune response in COVID-19 infected, recovered and vaccinated individuals.Immunobiology · 2023Article
- The association of decreased HLA-GMicrobial pathogenesis · 2022Article
- Cellular heterogeneity in disease severity and clinical outcome: Granular understanding of immune response is key.Frontiers in immunology · 2022Review
- Single-cell multiomics revealed the dynamics of antigen presentation, immune response and T cell activation in the COVID-19 positive and recovered individuals.Frontiers in immunology · 2022Article
- Molecular docking and molecular dynamics study Lianhua Qingwen granules (LHQW) treats COVID-19 by inhibiting inflammatory response and regulating cell survival.Frontiers in cellular and infection microbiology · 2022Article
- Review
- Reduced frequency of T helper 17 and T helper 1 cells and their association with critical coronavirus disease 2019.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2021Article
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Authors and funding
15 authors at 3 institutions in 2 countries.
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Abstract
There is very little knowledge about the immune responses, particularly cellular immunity to coronavirus disease 2019 (COVID-19). The main objective of this study was to evaluate the frequency of T helper (Th) cell subtypes, including Th1, Th17, and Treg cells, in moderate-to-severe and critical COVID-19 patients compared to healthy controls. Twenty-nine moderate-to-severe and 13 critical patients confirmed for COVID-19, and 15 healthy subjects were included in this study. Interferon-γ (IFN-γ)-producing Th1 and interleukin-17A-producing Th17 and Treg cells in peripheral blood were measured with flow cytometry. The frequency of Th1 and Th17 was significantly decreased in critical patients compared to healthy subjects (aMD: -2.76 and - 2.34) and moderate-to-severe patients (aMD: -1.89 and - 1.89), respectively (p < 0.05). Differences were not significant between moderate-to-severe patients and healthy subjects for both Th1 (p = 0.358) and Th17 (p = 0.535), respectively. In contrast, significant difference was not observed between study subjects regarding the frequency of Treg cells. Patients with critical COVID-19 had a markedly lower Th1/Treg and Th17/Treg ratios compared with the controls and moderate-to-severe cases. Our study showed a dysregulated balance of Th1 and Th17 cells and its relation to the severity of COVID-19.
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