Evidence map›Paper›PMID 33791972›Full record

ArticleAdvances in experimental medicine and biology2021

NMR-Based Metabolomics.

G A Nagana Gowda, Daniel Raftery

Abstract read
In one paragraph

Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
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  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Metabolic footprint of sepsis and septic shock: A narrative review.World journal of critical care medicine · 2026
    Review
  11. Review
  12. Guidelines for evaluating endothelial function in vascular tissue.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  13. Special Issue "Application of NMR Spectroscopy in Biomolecules".International journal of molecular sciences · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Metabolomics: A Viable Approach to Understand the Pathogenesis of Reactive ArthritisEndocrine, metabolic & immune disorders drug targets · 2026
    Review
  19. Review
  20. High-ResolutionMolecules (Basel, Switzerland) · 2025
    Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

G A Nagana GowdaNorthwest Metabolomics Research Center, Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA. ngowda@uw.edu.
Daniel RafteryNorthwest Metabolomics Research Center, Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4M
Modeling Homeostasis of Human Blood MetabolitesR01GM131491 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAFTERY, DANIEL, ZHANG, DABAO · 2020 to 2023
$2.2M
NCI NIH HHS P30 CA015704NIGMS NIH HHS R01 GM131491
6 · The paper itself

Abstract

Nuclear magnetic resonance (NMR) spectroscopy is a major analytical method used in the growing field of metabolomics. Although NMR is relatively less sensitive than mass spectrometry, this analytical platform has numerous characteristics including its high reproducibility and quantitative abilities, its nonselective and noninvasive nature, and the ability to identify unknown metabolites in complex mixtures and trace the downstream products of isotope labeled substrates ex vivo, in vivo, or in vitro. Metabolomic analysis of highly complex biological mixtures has benefitted from the advances in both NMR data acquisition and analysis methods. Although metabolomics applications span a wide range of disciplines, a majority has focused on understanding, preventing, diagnosing, and managing human diseases. This chapter describes NMR-based methods relevant to the rapidly expanding metabolomics field.

Indexed as

Magnetic Resonance ImagingMetabolomicsHumansMagnetic Resonance SpectroscopyMass SpectrometryReproducibility of Results1D NMR2D NMRFast NMR methodsIsotope taggingMetabolomicsNuclear magnetic resonance (NMR)

Identifiers

PMID33791972
PMCPMC8816450

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.