ArticleWiener klinische Wochenschrift2021
Micro-CT evaluation of historical human skulls presenting signs of syphilitic infection.
Article in Wiener klinische Wochenschrift, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- An Investigation of Hyperostosis Frontalis Interna in a Modern Anatomical Body Donor Population.Clinical anatomy (New York, N.Y.) · 2026Article
- Diagnostic Methods Used in Detecting Syphilis in Paleopathological Research-A Literature Review.Diagnostics (Basel, Switzerland) · 2025Review
- Headache as an Initial Manifestation of Syphilis Infection in a Young Woman: A Case Report and Literature Review.NMC case report journal · 2025Article
- Microarchitecture of historic bone samples with tuberculosis.Wiener klinische Wochenschrift · 2022Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn tertiary syphilis, Treponema pallidum triggers the formation of granulomatous nodules in various organs of the human body. Within the skeleton, predominantly in the skull and long bones, these characteristic syphilitic lesions cause typical patterns of bone damage. In this study, micro-computed tomography (µ-CT) was used to assess the microarchitecture of these osseous defects in untreated syphilitic skull bones. MATERIAL AND
methodsBone structure of 30 macerated human skulls was noninvasively examined by means of µ-CT images (Viscom X8060 NDT). A total of 20 specimens showing typical morphological signs of syphilis were provided by the Collection of Anatomical Pathology of the Museum of Natural History in Vienna. They were compared to 10 macerated control skulls provided by the Division of Anatomy of the Medical University of Vienna.
resultsAll samples affected by syphilis showed perforating defects and increased porosity. Furthermore, we observed sclerotic reorganization and complete loss of the cortical bone in 80% of infected cases. Cortical thinning occurred in 75%.
conclusionOur findings revealed extensive micromorphological bone destruction and a broad variability of osseous manifestations of (tertiary) syphilis.
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