ArticleJournal of neurology2021
Long-term analysis of patients with benign multiple sclerosis: new insights about the disability course.
Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Did COVID-19 Pandemic Change the Course of Multiple Sclerosis? A Retrospective Eight-Year Study.Health science reports · 2025Article
- Benign multiple sclerosis and long-term outcomes after 30 years.Journal of neurology · 2025Article
- Predictive factors and treatment challenges in malignant progression of relapsing-remitting multiple sclerosis.Heliyon · 2024Article
- Multiple sclerosis: time for early treatment with high-efficacy drugs.Journal of neurology · 2024Review
- Absence of Oligoclonal Bands in Multiple Sclerosis: A Call for Differential Diagnosis.Journal of clinical medicine · 2023Article
- Movement Disorders in Demyelinating Disorders: How Important Is This Historical Link Today?Annals of Indian Academy of NeurologyArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo describe the course of disability in patients with benign multiple sclerosis-i.e., with an expanded disability status scale score < 3 10 years after disease onset-for up to 30 years after disease onset. We evaluated the proportion of patients remaining in the benign state on the long term and the factor associated with this favorable outcome and determined the pattern of disability course after the loss of the benign status.
methodsPatients were selected from the ReLSEP, a French population-based registry. We studied the probability (Kaplan-Meier method) and predictors (multivariate Cox model) of remaining < 3 after year 10, and the course of disability after score 3 according to the duration of the benign phase in patients with ≥ 30 years of follow-up (graphs of the course of the mean expanded disability status scale scores in subgroups of patients).
results2295/3440 patients had benign multiple sclerosis (66.7%). The probability of remaining benign at year 30 was 0.26 (95% CI 0.26-0.32). A young age at disease onset and a good recovery after the first relapse were associated with remaining benign. Graphs illustrate that those who lost their benign status between years 10 and 30 follow a two-stage course. Beyond score 3, disability accumulation is similar in all but lower disability scores at advanced age are associated with longer benign periods.
conclusionThe longer a patient remains in the benign state, the lower the final EDSS at advanced age.
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