ArticleCerebral cortex (New York, N.Y. : 1991)2021
Age-Related Differences in White Matter: Understanding Tensor-Based Results Using Fixel-Based Analysis.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Streamline-Based Analysis: A novel framework for tractogram-driven streamline-wise statistical inference.Research square · 2026Article
- White matter microstructural alterations correlate with clinical characteristics in craniocervical dystonia.Neuroradiology · 2026Article
- Fixel‑based analysis reveals distributed white matter alterations associated with pain severity in trigeminal neuralgia.The journal of headache and pain · 2026Article
- Age-group differences in diffusion MRI characteristics of cortico-cerebellar tracts and their association with bimanual performance.Frontiers in aging neuroscience · 2026Article
- Psychotic-Like Experiences and White Matter Microstructure: A Fixel-Based Analysis Approach With Robust Replication Across Two Cohorts.Human brain mapping · 2025Article
- Motor-cognitive aging: The role of motor cortex and its pathways.NeuroImage · 2025Article
- Cross-Sectional and Longitudinal Associations Between Olfaction and White-Matter Integrity Across the Lifespan.Human brain mapping · 2025Article
- Brain Microstructural Alteration and Its Implications for Postoperative Delirium in Elderly Surgical Patients: A Narrative Review.Brain and behavior · 2025Review
- Network control theory uncovers aberrant connectome controllability in trigeminal neuralgia.The journal of headache and pain · 2025Article
- Quantifying neurodegeneration within subdivisions of core motor pathways in amyotrophic lateral sclerosis using diffusion MRI.Journal of neurology · 2025Article
- Understanding Cognitive Aging Through White Matter: A Fixel-Based Analysis.Human brain mapping · 2024Article
- Exploring the neuroprotective role of physical activity in cerebral small vessel disease.Brain research · 2024Review
- The Role of Conscious and Unconscious Proprioceptive Sensation in Unstable Postural Balance: A Cross-Sectional Study.Journal of clinical practice and research · 2024Article
- White matter differences between younger and older adults revealed by fixel-based analysis.Aging brain · 2024Article
- Aerobic exercise is associated with region-specific changes in volumetric, tensor-based, and fixel-based measures of white matter integrity in healthy older adults.Neuroimage. Reports · 2023Article
- The effect of aging, hearing loss, and tinnitus on white matter in the human auditory system revealed with fixel-based analysis.Frontiers in aging neuroscience · 2023Article
- The role of corticospinal and extrapyramidal pathways in motor impairment after stroke.Brain communications · 2023Article
- Longitudinal patterns of white matter fibre density and morphology in children are associated with age and pubertal stage.Developmental cognitive neuroscience · 2020Article
- TRAMFIX: TRavelling Across Melbourne for FIXel-based analysis (a reproducibility and reliability study).Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Aging is associated with widespread alterations in cerebral white matter (WM). Most prior studies of age differences in WM have used diffusion tensor imaging (DTI), but typical DTI metrics (e.g., fractional anisotropy; FA) can reflect multiple neurobiological features, making interpretation challenging. Here, we used fixel-based analysis (FBA) to investigate age-related WM differences observed using DTI in a sample of 45 older and 25 younger healthy adults. Age-related FA differences were widespread but were strongly associated with differences in multi-fiber complexity (CX), suggesting that they reflected differences in crossing fibers in addition to structural differences in individual fiber segments. FBA also revealed a frontolimbic locus of age-related effects and provided insights into distinct microstructural changes underlying them. Specifically, age differences in fiber density were prominent in fornix, bilateral anterior internal capsule, forceps minor, body of the corpus callosum, and corticospinal tract, while age differences in fiber cross section were largest in cingulum bundle and forceps minor. These results provide novel insights into specific structural differences underlying major WM differences associated with aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.