ArticleCerebral cortex (New York, N.Y. : 1991)2021
Supplementary and Premotor Aspects of the Corticospinal Tract Show Links with Restricted and Repetitive Behaviors in Middle-Aged Adults with Autism Spectrum Disorder.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Cognitive and Cerebral Aging Research in Autism: A Systematic Review on an Emerging Topic.Autism research : official journal of the International Society for Autism Research · 2025Pooled it
- Biopsychological correlates of repetitive and restricted behaviors in autism spectrum disorders.Brain and behavior · 2021Pooled it
- Autism Spectrum Disorder in adults: an integrative review about strategies for promotion and maintenance of quality of life.Sao Paulo medical journal = Revista paulista de medicina · 2025Review
- Neurofeedback training of executive function in autism spectrum disorder: distinct effects on brain activity levels and compensatory connectivity changes.Journal of neurodevelopmental disorders · 2024Article
- Cortico-basal ganglia white matter microstructure is linked to restricted repetitive behavior in autism spectrum disorder.Molecular autism · 2024Article
- Community-based postural control assessment in autistic individuals indicates a similar but delayed trajectory compared to neurotypical individuals.Autism research : official journal of the International Society for Autism Research · 2023Article
- Restricted and repetitive behaviors and association with cognition and adaptive functioning in children with autism spectrum disorder in Singapore.Frontiers in psychiatry · 2023Article
- Emerging signs of autism spectrum disorder in infancy: Putative neural substrate.Developmental medicine and child neurology · 2022Review
- White matter microstructural and morphometric alterations in autism: implications for intellectual capabilities.Molecular autism · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Individuals with autism spectrum disorder (ASD) show motor impairment into adulthood and risk decline during aging, but little is known about brain changes in aging adults with ASD. Few studies of ASD have directly examined the corticospinal tract (CST)-the major descending pathway in the brain responsible for voluntary motor behavior-outside its primary motor (M1) connections. In 26 middle-aged adults with ASD and 26 age-matched typical comparison participants, we used diffusion imaging to examine the microstructure and volume of CST projections from M1, dorsal premotor (PMd), supplementary motor area (SMA), and primary somatosensory (S1) cortices with respect to age. We also examined relationships between each CST sub-tract (-cst), motor skills, and autism symptoms. We detected no significant group or age-related differences in tracts extending from M1 or other areas. However, sub-tracts of the CST extending from secondary (but not primary) motor areas were associated with core autism traits. Increased microstructural integrity of left PMd-cst and SMA-cst were associated with less-severe restricted and repetitive behaviors (RRB) in the ASD group. These findings suggest that secondary motor cortical areas, known to be involved in selecting motor programs, may be implicated in cognitive motor processes underlying RRB in ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.