Evidence map›Paper›PMID 33791742›Full record

ArticlemedRxiv : the preprint server for health sciences2021

From loss to recovery: how to effectively assess chemosensory impairments during COVID-19 pandemic.

Cinzia Cecchetto, Antonella Di Pizio, Federica Genovese, Orietta Calcinoni, Alberto Macchi, Andreas Dunkel, Kathrin Ohla, Sara Spinelli, Michael C Farruggia, Paule V Joseph and 8 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 11 institutions in 3 countries.

Cinzia CecchettoDepartment of General Psychology, University of Padova, Italy.
Antonella Di PizioLeibniz-Institute for Food Systems Biology at the Technical University of Munich, Germany.
Federica GenoveseDepartment of Physiology, Monell Chemical Senses Center, USA.
Orietta CalcinoniPrivate practice VMPCT, Milan, Italy.
Alberto MacchiENT department, Italian Academy Of Rhinology - ASST sette laghi Varese.
Andreas DunkelLeibniz-Institute for Food Systems Biology at the Technical University of Munich, Germany.
Kathrin OhlaInstitute of Psychology, University of Muenster, Germany.
Sara SpinelliDepartment of Agriculture, Food, Environment and Forestry (DAGRI), University of Florence, Italy.
Michael C FarruggiaInterdepartmental Neuroscience Program, Yale University, USA.
Paule V JosephNational Institutes of Nursing Research.
Anna MeniniNeurobiology Section, SISSA, International School for Advanced Studies, Italy.
Elena CantoneDepartment of Neuroscience, ENT section, Federico II University of Naples, Italy.
Caterina DinnellaDepartment of Agriculture, Food, Environment and Forestry (DAGRI), University of Florence, Italy.
Maria Paola CecchiniDepartment of Neurosciences, Biomedicine and Movement Sciences, Anatomy and Histology Section, University of Verona, Italy.
Anna D'ErricoDepartment of Neurobiology, Goethe Universität Frankfurt, Germany.
Carla Mucignat-CarettaDepartment of Molecular Medicine, University of Padova, Italy.
Valentina ParmaDepartment of Physiology, Monell Chemical Senses Center, USA.
Michele DibattistaDepartment of Basic Medical Sciences, University of Bari A. Moro.
Leibniz-Institute for Food Systems Biology at the Technical University of Munich · DEMonell Chemical Senses Center · USUniversity of Florence · ITUniversity of Padua · ITAziende Socio Sanitarie Territoriale dei Sette LaghiGoethe University Frankfurt · DENational Institutes of Health · USScuola Internazionale Superiore di Studi Avanzati · ITUniversity of Bari Aldo Moro · ITUniversity of Verona · ITYale University · US

Funding

Sensory Science and Metabolism; Molecular and Neuronal Mechanisms ZIAAA000136 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI JOSEPH, PAULE · 2021 to 2025
$3.2M
Trigeminal Modulation of Olfactory Responses in the Main Olfactory EpitheliumR21DC018358 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI GENOVESE, FEDERICA · 2020 to 2022
$465k
NIDCD NIH HHS R21 DC018358
6 · The paper itself

Abstract

Chemosensory impairments have been established as a specific indicator of COVID-19. They affect most patients and may persist long past the resolution of respiratory symptoms, representing an unprecedented medical challenge. Since the SARS-CoV-2 pandemic started, we now know much more about smell, taste, and chemesthesis loss associated with COVID-19. However, the temporal dynamics and characteristics of recovery are still unknown. Here, capitalizing on data from the Global Consortium for Chemosensory Research (GCCR) crowdsourced survey, we assessed chemosensory abilities after the resolution of respiratory symptoms in participants diagnosed with COVID-19 during the first wave of the pandemic in Italy. This analysis led to the identification of two patterns of chemosensory recovery, limited (partial) and substantial, which were found to be associated with differential age, degrees of chemosensory loss, and regional patterns. Uncovering the self-reported phenomenology of recovery from smell, taste, and chemesthetic disorders is the first, yet essential step, to provide healthcare professionals with the tools to take purposeful and targeted action to address chemosensory disorders and its severe discomfort.

Identifiers

PMID33791742
PMCPMC8010774
OpenAlexW3145311255

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.