ArticleAesthetic surgery journal. Open forum2020
New Mechanical Fat Separation Technique: Adjustable Regenerative Adipose-tissue Transfer (ARAT) and Mechanical Stromal Cell Transfer (MEST).
Article in Aesthetic surgery journal. Open forum, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Mechanical isolation of stromal vascular fraction from adipose tissue: methods and cellular outcomes: a systematic review and meta-analysis.Stem cell research & therapy · 2025Pooled it
- Not Stromal Vascular Fraction (SVF) or Nanofat, but Total Stromal-Cells (TOST): A New Definition. Systemic Review of Mechanical Stromal-Cell Extraction Techniques.Tissue engineering and regenerative medicine · 2021Pooled it
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- Uniform Treatment Protocol With Hybrid Stromal Vascular Fraction and Platelet-Rich Plasma on Micro-Fat Grafting With Facelifting: A Preliminary Retrospective 3D Vectra Observational Study.Aesthetic surgery journal. Open forum · 2026Article
- Impact of processing steps on cellular content of mechanical isolated stromal vascular fraction.Frontiers in bioengineering and biotechnology · 2026Article
- A modified technique for mechanical isolation of stromal vascular fraction yields increased final product volume and high viable nucleated cells count.Journal of experimental orthopaedics · 2025Article
- Innovative Mechanical Processing of Adipose Tissue: A Comparative Evaluation of Microfat and Concentrated Micronized Fat for Superficial Fat Grafting.Aesthetic plastic surgery · 2025Article
- Advanced methods to mechanically isolate stromal vascular fraction: A concise review.Regenerative therapy · 2024Review
- Autologization of Exosomes with Deparenchymized Adipose Tissue: An Innovative Approach for Regenerative Medicine and Surgery.Plastic and reconstructive surgery. Global open · 2024Article
- Non-enzymatic methods for isolation of stromal vascular fraction and adipose-derived stem cells: A systematic review.World journal of methodology · 2024Article
- A Simple and Effective Mechanical Method for Adipose-Derived Stromal Vascular Fraction Isolation.Cureus · 2024Article
- Mechanical Fractionation of Adipose Tissue-A Scoping Review of Procedures to Obtain Stromal Vascular Fraction.Bioengineering (Basel, Switzerland) · 2023Article
- A New Classification for Adipose-derived Stromal-cell Systems.Plastic and reconstructive surgery. Global open · 2022Article
- The composition of cell-based therapies obtained from point-of-care devices/systems which mechanically dissociate lipoaspirate: a scoping review of the literature.Journal of experimental orthopaedics · 2022Article
- Review
- Facial Fat Grafting (FFG): Worth the Risk? A Systematic Review of Complications and Critical Appraisal.Journal of clinical medicine · 2022Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdipose tissue is not only a very important source of filler but also the body's greatest source of regenerative cells.
objectivesIn this study, adipose tissue was cut to the desired dimensions using ultra-sharp blade systems to avoid excessive blunt pressure and applied to various anatomical areas-a procedure known as adjustable regenerative adipose-tissue transfer (ARAT). Mechanical stromal cell transfer (MEST) of regenerative cells from fat tissue was also examined.
methodsARAT, MEST, or a combination of these was applied in the facial area of a total of 24 patients who were followed for at least 24 months. The integrity of the fat tissue cut with different diameter blades is shown histopathologically. The number and viability of the stromal cells obtained were evaluated and secretome analyses were performed. Patient and surgeon satisfaction were assessed with a visual analog scale.
resultsWith the ARAT technique, the desired size fat grafts were obtained between 4000- and 200-micron diameters and applied at varying depths to different aesthetic units of the face, and a guide was developed. In MEST, stromal cells were obtained from 100 mL of condensed fat using different indication-based protocols with 93% mean viability and cell counts of 28.66 to 88.88 × 10
conclusionsThere are 2 main complications in fat grafting: visibility in thin skin and a low retention rate. The ARAT technique can be used to prevent these 2 complications. MEST, on the other hand, obtains a high rate of fat and viable stromal cells without applying excessive blunt pressure. LEVEL OF EVIDENCE 4:
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.