ArticleAesthetic surgery journal. Open forum2019
Cellular Optimization of Nanofat: Comparison of Two Nanofat Processing Devices in Terms of Cell Count and Viability.
Article in Aesthetic surgery journal. Open forum, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Analyzing the Clinical Potential of Stromal Vascular Fraction: A Comprehensive Literature Review.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Stromal Vascular Fraction Therapy for Knee Osteoarthritis: A Systematic Review.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Not Stromal Vascular Fraction (SVF) or Nanofat, but Total Stromal-Cells (TOST): A New Definition. Systemic Review of Mechanical Stromal-Cell Extraction Techniques.Tissue engineering and regenerative medicine · 2021Pooled it
- Comparing mechanical and enzymatic isolation procedures to isolate adipose-derived stromal vascular fraction: A systematic review.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyPooled it
- Cryopreservation of adipose tissue for nanofat production: biological principles, workflow standardisation, and regulated biobanking.Cell and tissue banking · 2026Review
- Nanofat in Plastic Surgery: A Systematic Review of Clinical Outcomes, Safety, and Emerging Applications.Plastic and reconstructive surgery. Global open · 2026Article
- Nanofat for Injection Laryngoplasty: Office and Operative Results.Laryngoscope investigative otolaryngology · 2026Article
- Molecular and Cellular Analysis of Lipogems-Processed Lipoaspirates for Evaluating the Efficacy of Treatments in Regenerative Medicine.Stem cell reviews and reports · 2026Article
- First comparison of commercial systems to prepare nanofat: technical performances and biological quality differ among obtained products.Scientific reports · 2026Article
- Uniform Treatment Protocol With Hybrid Stromal Vascular Fraction and Platelet-Rich Plasma on Micro-Fat Grafting With Facelifting: A Preliminary Retrospective 3D Vectra Observational Study.Aesthetic surgery journal. Open forum · 2026Article
- Recombinant Platelet-Derived Growth Factor BB vs Autologous Nanofat to Enhance Recovery After COAesthetic surgery journal. Open forum · 2026Article
- Improvement in nanofat preparation technology: Simple and easy-to-use adipose tissue harvesting with Liporevive.JPRAS open · 2025Article
- Clinical practice perspectives on adipose-derived stem cells and platelet-rich plasma for female infertility treatments.Future science OA · 2025Review
- Comparative outcome analyses of stromal vascular fractionWorld journal of experimental medicine · 2025Article
- Integrated Fluidic Platform for Washing and Mechanical Processing of Lipoaspirate for Downstream Fat Grafting and Regenerative Applications.Bioengineering (Basel, Switzerland) · 2025Article
- A modified technique for mechanical isolation of stromal vascular fraction yields increased final product volume and high viable nucleated cells count.Journal of experimental orthopaedics · 2025Article
- Current status of nanofat in the management of knee osteoarthritis: A systematic review.World journal of orthopedics · 2025Article
- Filtered and unfiltered lipoaspirates reveal novel molecular insights and therapeutic potential for osteoarthritis treatment: a preclinicalFrontiers in cell and developmental biology · 2025Article
- Advanced methods to mechanically isolate stromal vascular fraction: A concise review.Regenerative therapy · 2024Review
- Nanofat Improves Vascularization and Tissue Integration of Dermal Substitutes without Affecting Their Biocompatibility.Journal of functional biomaterials · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNanofat was introduced by Tonnard and Verpaele in 2013. Their initial observations in intradermal applications showed improvement in the appearance of the skin. Since then, a number of Nanofat devices have been introduced. The cellular content in the processing of Nanofat is not the same in every device, yet the cellular composition is responsible for the biologic action of Nanofat. The authors sought to find a different means to produce a matrix rich Nanofat to optimize the cellular content.
objectivesThe primary objective of this study was to compare cell counts, cultures, and cell viabilities produced by LipocubeNano (Lipocube, Inc., London, UK) in comparison to Tulip's NanoTransfer (Tulip Medical, San Diego, CA) processing methods.
methodsTwenty milliliters of fat were harvested from 10 patients in order to test two methods of Nanofat production. Ten milliliters of fat were used to assess each method and, after the final product was obtained, enzymatic digestion for stromal vascular fraction (SVF) isolation was performed. A Muse Flow-cytometer was used to measure cell counts and cell viabilities, cell cultures were performed, and cell images were taken with a florescent microscope.
resultsThe LipocubeNano was shown to be superior to Tulip's NanoTransfer system of progressive downsizing with final filtering, which appeared to trap more fibrous tissue leading to lower amounts of SVF. LipocubeNano resulted in higher cell counts (2.24 × 10
conclusionsNanofat from LipocubeNano has a higher regenerative cell count and more SVF cells than the other common mechanical method of Nanofat processing. This new means of mechanical processing preserves more matrix, optimizing the cellular content of the Nanofat, thus having potentially a higher regenerative effect. LEVEL OF EVIDENCE 5:
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.