ArticleChem2019
Determinants of Ion-Transporter Cancer Cell Death.
Article in Chem, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 101 citations in OpenAlex.
- Lysosome-Targeted Squaramide Anion Transporters.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Lipophilic mono-guanidinesRSC advances · 2026Article
- Steric Control of Cooperative Anion Transport Mediated by β- and δ‑Hexachlorocyclohexane Multivalent Carriers.JACS Au · 2026Article
- Near-Infrared Triggered Anion Transport Induces Cancer Cell Death.Angewandte Chemie (International ed. in English) · 2026Article
- Chlorination-Enhanced HChemistry, an Asian journal · 2026Article
- Hemi-Indigiosin: A pH and Red-Light Responsive Transmembrane HCl Transporter.Angewandte Chemie (International ed. in English) · 2025Article
- The Dynamic Chemistry of Orthoesters and Trialkoxysilanes: Making Supramolecular Hosts Adaptive, Fluxional, and Degradable.Accounts of chemical research · 2024Article
- Investigation of the Ability to Detect Electrolyte Disorder Using PET with Positron Annihilation Lifetime Spectroscopy.The journal of physical chemistry. B · 2023Article
- Photoswitchable Bis(amidopyrroles): Modulating Anion Transport Activity Independent of Binding Affinity.The Journal of organic chemistry · 2023Article
- Fatty Acid-Activated Proton Transport by Bisaryl Anion Transporters Depolarises Mitochondria and Reduces the Viability of MDA-MB-231 Breast Cancer Cells.Biomolecules · 2023Article
- Stimulus-Controlled Anion Binding and Transport by Synthetic Receptors.Chemical reviews · 2023Review
- Voltage imaging reveals the dynamic electrical signatures of human breast cancer cells.Communications biology · 2022Article
- pH-Dependent transport of amino acids across lipid bilayers by simple monotopic anion carriers.Chemical science · 2022Article
- Synthesis and mechanism of biological action of morpholinyl-bearing arylsquaramides as small-molecule lysosomal pH modulators.RSC advances · 2022Article
- Measuring anion binding at biomembrane interfaces.Nature communications · 2022Article
- Dynamic Covalent Self-Assembly of Chloride- and Ion-Pair-Templated Cryptates.Angewandte Chemie (International ed. in English) · 2022Article
- Ion Channels and Transporters as Therapeutic Agents: From Biomolecules to Supramolecular Medicinal Chemistry.Biomedicines · 2022Review
- Photomodulation of Transmembrane Transport and Potential by Stiff-Stilbene Based Bis(thio)ureas.Journal of the American Chemical Society · 2022Article
- The crosstalk effect between ferrous and other ions metabolism in ferroptosis for therapy of cancer.Frontiers in oncology · 2022Review
- CLN7 is an organellar chloride channel regulating lysosomal function.Science advances · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
Recently, we showed that synthetic anion transporters DSC4P-1 and SA-3 had activity related to cancer cell death. They were found to increase intracellular chloride and sodium ion concentrations. They were also found to induce apoptosis (DSC4P-1) and both induce apoptosis and inhibit autophagy (SA-3). However, determinants underlying these phenomenological findings were not elucidated. The absence of mechanistic understanding has limited the development of yet-improved systems. Here, we show that three synthetic anion transporters, DSC4P-1, SA-3, and 8FC4P, induce osmotic stress in cells by increasing intracellular ion concentrations. This triggers the generation of reactive oxygen species via a sequential process and promotes caspase-dependent apoptosis. In addition, two of the transporters, SA-3 and 8FC4P, induce autophagy by increasing the cytosolic calcium ion concentration promoted by osmotic stress. However, they eventually inhibit the autophagy process as a result of their ability to disrupt lysosome function through a transporter-mediated decrease in a lysosomal chloride ion concentration and an increase in the lysosomal pH.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.