Evidence map›Paper›PMID 33791394›Full record

ArticleGE Portuguese journal of gastroenterology2021

Long-Term Follow-Up of a Portuguese Single-Centre Cohort of Persons with Haemophilia and Hepatitis C Virus Infection.

Tiago Pereira Guedes, Mónica Garrido, Ricardo Kuttner Magalhães, Teresa Moreira, Marta Rocha, Luís Maia, José Manuel Ferreira, Sara Morais, Isabel Pedroto

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GE Portuguese journal of gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tiago Pereira GuedesGastroenterology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Mónica GarridoGastroenterology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Ricardo Kuttner MagalhãesGastroenterology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Teresa MoreiraGastroenterology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Marta RochaGastroenterology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Luís MaiaGastroenterology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.
José Manuel FerreiraGastroenterology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Sara MoraisHaematology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Isabel PedrotoGastroenterology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Centro Hospitalar do Porto · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPersons with haemophilia (PWH) used to represent a population with a high prevalence of hepatitis C virus (HCV) infection due to the use of contaminated blood products. Although the goals of antiviral therapy are the same as the general population, long real-life follow-up data regarding their outcomes are still scarce. Our aim was to report the outcomes of HCV infection and the results of antiviral therapy in PWH.

methodsA retrospective analysis was performed in a single-centre cohort of PWH with positive HCV antibody. Outcomes registered were rate of spontaneous clearance of HCV, sustained virologic response (SVR) achievement, development of end-stage liver disease, and all-cause and liver-related mortality.

resultsOut of 131 PWH, 73 (55.7%) had positive HCV antibody. During a median follow-up time of 22 years, 46 patients (63.9%) developed chronic hepatitis C, of which 16 (34.8%) developed cirrhosis. Treatment was pursued in 34 PWH. Most (

conclusionsWe describe the outcomes of a cohort of Portuguese PWH and hepatitis C exposure after two decades of follow-up, with a lower mortality than previously described. Our response rates to HCV treatment were comparable to those in the general population and stress the importance of early treatment.

Indexed as

Direct-acting antiviralsEnd-stage liver diseaseHaemophilia AHaemophilia BHepatitis C, chronic

Identifiers

PMID33791394
PMCPMC7991614
OpenAlexW3089879974

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.