Evidence map›Paper›PMID 33791306›Full record

ArticleFrontiers in cell and developmental biology2021

Low-Dose Decitabine Augments the Activation and Anti-Tumor Immune Response of IFN-γ

Xiang Li, Liang Dong, Jiejie Liu, Chunmeng Wang, Yan Zhang, Qian Mei, Weidong Han, Ping Xie, Jing Nie

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Identification and validation of a CD4BMC gastroenterology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. [Exploration of CAR-T cell combination therapy strategies in lymphoma].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2022
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xiang LiDepartment of Cell Biology, The Municipal Key Laboratory for Liver Protection and Regulation of Regeneration, Capital Medical University, Beijing, China.
Liang DongDepartment of Bio-therapeutic, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Jiejie LiuDepartment of Bio-therapeutic, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Chunmeng WangDepartment of Bio-therapeutic, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Yan ZhangDepartment of Bio-therapeutic, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Qian MeiDepartment of Bio-therapeutic, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Weidong HanDepartment of Bio-therapeutic, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Ping XieDepartment of Cell Biology, The Municipal Key Laboratory for Liver Protection and Regulation of Regeneration, Capital Medical University, Beijing, China.
Jing NieDepartment of Bio-therapeutic, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Chinese PLA General Hospital · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCD4

methodsThe effects of low-dose decitabine on sorted CD4

resultsLow-dose decitabine treatment promoted the proliferation and activation of sorted CD4

conclusionThese data suggest that low-dose decitabine potentiates CD4

Indexed as

CD4+ T cellsdecitabineimmune responseIκBα degradationNF-κB activation

Identifiers

PMID33791306
PMCPMC8005576
OpenAlexW3138331271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.