Evidence map›Paper›PMID 33791245›Full record

ArticleFrontiers in cellular and infection microbiology2021

Gut Microbiome Alterations in Patients With Thyroid Nodules.

Ang Li, Tiantian Li, Xinxin Gao, Hang Yan, Jingfeng Chen, Meng Huang, Lin Wang, Detao Yin, Hongqiang Li, Runsheng Ma and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Microbiota and Thyroid Disease: An Updated Systematic Review.Advances in experimental medicine and biology · 2023
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  18. Frontiers in cellular and infection microbiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ang LiHealth Management Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Tiantian LiHealth Management Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xinxin GaoHealth Management Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Hang YanHealth Management Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jingfeng ChenHealth Management Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Meng HuangHealth Management Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Lin WangHealth Management Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Detao YinDepartment of Thyroidology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Hongqiang LiDepartment of Thyroidology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Runsheng MaDepartment of Thyroidology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Qiang ZengHealth Management Institute，The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
Suying DingHealth Management Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
First Affiliated Hospital of Zhengzhou University · CNChinese PLA General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thyroid nodules are found in nearly half of the adult population. Accumulating evidence suggests that the gut microbiota plays an important role in thyroid metabolism, yet the association between gut microbiota capacity, thyroid nodules, and thyroid function has not been studied comprehensively. We performed a gut microbiome genome-wide association study in 196 patients with thyroid nodules and 283 controls by using whole-genome shotgun sequencing. We found that participants with high-grade thyroid nodules have decreased number of gut microbial species and gene families compared with those with lower grade nodules and controls. There are also significant alterations in the overall microbial composition in participants with high-grade thyroid nodules. The gut microbiome in participants with high-grade thyroid nodules is characterized by greater amino acid degradation and lower butyrate production. The relative abundances of multiple butyrate producing microbes are reduced in patients with high-grade thyroid nodules and the relative abundances of L-histidine metabolism pathways are associated with thyrotropin-releasing hormone. Our study describes the gut microbiome characteristics in thyroid nodules and a gut-thyroid link and highlight specific gut microbiota as a potential therapeutic target to regulate thyroid metabolism.

Indexed as

Gastrointestinal MicrobiomeThyroid NoduleAdultButyratesGenome-Wide Association StudyHumansMetagenomicsButyratescomparative genomicsgut microbiotagut-thyroid linkmetagenomicsthyroid functionthyroid nodule

Identifiers

PMID33791245
PMCPMC8005713
OpenAlexW3136667010

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.