ArticleFrontiers in cellular and infection microbiology2021
Probing the "Dark Matter" of the Human Gut Phageome: Culture Assisted Metagenomics Enables Rapid Discovery and Host-Linking for Novel Bacteriophages.
Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 43 citations in OpenAlex.
- Fecal filtrate transplantation as salvage therapy for fulminantGut microbes · 2026Trial
- Gut virome-microbiome interactions across hosts and environments.NPJ biofilms and microbiomes · 2026Article
- Bacteriophages in gut metagenomes: from analysis to application.Virology journal · 2026Review
- Isolation and characterization of a novel lytic bacteriophage forGut microbes reports · 2026Article
- The role of the early-life gut microbiome in childhood asthma.Gut microbes · 2025Review
- Effects of bacteriophages on gut microbiome functionality.Gut microbes · 2025Review
- Identification and characterization ofMicrobiology spectrum · 2025Article
- Mobile genetic elements: the hidden puppet masters underlying infant gut microbiome assembly?Microbiome research reports · 2025Article
- Human Gut Bacteriophageome: Insights Into Drug Resistance Mechanisms in Tuberculosis.Interdisciplinary perspectives on infectious diseases · 2025Review
- A roadmap of isolating and investigating bacteriophage infecting human gut anaerobes.Essays in biochemistry · 2024Review
- How to introduce a new bacteriophage on the block: a short guide to phage classification.Journal of virology · 2024Review
- DeepPL: A deep-learning-based tool for the prediction of bacteriophage lifecycle.PLoS computational biology · 2024Article
- Dietary Effects on the Gut Phageome.International journal of molecular sciences · 2024Review
- Characterization of the gut bacterial and viral microbiota in latent autoimmune diabetes in adults.Scientific reports · 2024Article
- Reuse, Repurpose, and Recycle: Bacteriophages and Microbial Surveillance (1921-2023).PHAGE (New Rochelle, N.Y.) · 2024Review
- Article
- The gut virome is associated with stress-induced changes in behaviour and immune responses in mice.Nature microbiology · 2024Article
- Bacteriophage-Host Interactions and Coevolution.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Review
- Genomes of a Novel Group of Phages That Use Alternative Genetic Code Found in Human Gut Viromes.International journal of molecular sciences · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent years have been marked by the growing interest towards virulent and temperate bacteriophage populations inhabiting the human lower gastrointestinal tract - the gut phageome. A number of studies demonstrated high levels of specificity and temporal stability of individual gut phageomes, as well as their specific alterations in disease cohorts, in parallel with changes in the bacteriome. It has been speculated that phages might have an active role in shaping the taxonomic composition and functional properties of the human gut bacteriome. An overwhelming majority of gut bacteriophages, however, remain uncultured, unclassified, and their specific hosts and infection strategies are still unknown. They are often referred to as "the viral dark matter". A possible breakthrough in understanding of the phageome can only become possible when a significant proportion of the "the viral dark matter" is identified and linked to bacterial hosts. Here, we describe a method that enables rapid discovery and host-linking of novel bacteriophages in the gut
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.