Evidence map›Paper›PMID 33791158›Full record

ArticleAmerican journal of cancer research2021

Genetic variations in base excision repair pathway genes and risk of hepatoblastoma: a seven-center case-control study.

Zhenjian Zhuo, Ao Lin, Jiao Zhang, Huitong Chen, Yong Li, Zhonghua Yang, Li Li, Suhong Li, Jiwen Cheng, Jing He

Open access · greenAbstract read
In one paragraph

Article in American journal of cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Journal of Cancer · 2022
    Article
  9. Article
  10. The Genetic Changes of Hepatoblastoma.Frontiers in oncology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Zhenjian ZhuoDepartment of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University Guangzhou 510623, Guangdong, China.
Ao LinDepartment of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University Guangzhou 510623, Guangdong, China.
Jiao ZhangDepartment of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, Henan, China.
Huitong ChenDepartment of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University Guangzhou 510623, Guangdong, China.
Yong LiDepartment of Pediatric Surgery, Hunan Children's Hospital Changsha 410004, Hunan, China.
Zhonghua YangDepartment of Pediatric Surgery, Shengjing Hospital of China Medical University Shenyang 110004, Liaoning, China.
Li LiKunming Key Laboratory of Children Infection and Immunity, Yunnan Key Laboratory of Children's Major Disease Research, Yunnan Institute of Pediatrics Research, Yunnan Medical Center for Pediatric Diseases, Kunming Children's Hospital Kunming 650228, Yunnan, China.
Suhong LiDepartment of Pathology, Children Hospital and Women Health Center of Shanxi Taiyuan 030013, Shanxi, China.
Jiwen ChengDepartment of Pediatric Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 710004, Shaanxi, China.
Jing HeDepartment of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University Guangzhou 510623, Guangdong, China.
Guangzhou Medical University · CNBoston Children's Museum · USChina Medical University · CNFirst Affiliated Hospital of Zhengzhou University · CNHunan Children's Hospital · CNSecond Affiliated Hospital of Xi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatoblastoma is a rare childhood liver cancer without known explicit etiology. Base excision repair (BER) pathway genes have been implicated in the pathophysiology of cancer, yet the role of BER pathway gene single nucleotide polymorphisms (SNPs) on hepatoblastoma risk still awaits to be explored. This study aims to determine whether hepatoblastoma risk be modulated by polymorphisms in the BER pathway genes based on genotyped data from 313 cases and 1446 controls. We applied TaqMan assay to genotype these included samples. We comprehensively genotyped 20 SNPs across six genes of BER, and estimated odds ratio (ORs), 95% confidence intervals (CIs), and

Indexed as

BERHepatoblastomapolymorphismsusceptibility

Identifiers

PMID33791158
PMCPMC7994175
OpenAlexW3141067325

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.