Evidence map›Paper›PMID 33791110›Full record

ArticleJournal of ultrasonography2021

Shear wave elastography detects novel imaging biomarkers of aromatase inhibitor-induced joint pain: a pilot study.

Jessica A Martinez, Mihra S Taljanovic, Russell S Witte, Andres A Nuncio Zuniga, Betsy C Wertheim, C Kent Kwoh, Brian A Goldstein, Denise J Roe, Pavani Chalasani

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ultrasonography, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 17 citations in OpenAlex.

  1. Musculoskeletal symptoms associated with aromatase inhibitors in the treatment of early breast cancer: A scoping review of risk factors and outcomes.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jessica A MartinezThe University of Arizona Cancer Center, Tucson, AZ, USA.
Mihra S TaljanovicDepartment of Medical Imaging, University of Arizona, Tucson, AZ, USA.
Russell S WitteThe University of Arizona Cancer Center, Tucson, AZ, USA.
Andres A Nuncio ZunigaDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ, USA.
Betsy C WertheimThe University of Arizona Cancer Center, Tucson, AZ, USA.
C Kent KwohDepartment of Medical Imaging, University of Arizona, Tucson, AZ, USA.
Brian A GoldsteinDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ, USA.
Denise J RoeThe University of Arizona Cancer Center, Tucson, AZ, USA.
Pavani ChalasaniThe University of Arizona Cancer Center, Tucson, AZ, USA.
University of Arizona · USUniversity of Arizona Cancer CenterBanner - University Medical Center Tucson · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo determine whether differences in joint and tendon stiffness as measured by ultrasound shear wave elastography are present in breast cancer patients with aromatase inhibitor-associated arthralgias compared to age-comparable healthy control women.

methodsPostmenopausal women with stage I-III breast cancer who were taking adjuvant aromatase inhibitors and complained of joint pain were enrolled (

resultsPatients with AI-associated arthralgias had significantly stiffer tendons than controls in the 1

conclusionsThis is the first study to identify increased tendon stiffness as a putative physiological characteristic of aromatase inhibitor-associated arthralgias. Future studies should determine whether increased tendon stiffness is a risk factor for the development of aromatase inhibitor-associated arthralgias, or a result of aromatase inhibitor treatment.

Indexed as

aromatase inhibitorsarthralgiabreast cancerDoppler ultrasoundshear wave elastography

Identifiers

PMID33791110
PMCPMC8008134
OpenAlexW3135589666

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.