Evidence map›Paper›PMID 33791062›Full record

ArticleThe Neurohospitalist2021

Critical Analysis of a Challenging Case of Post-Infectious N-Methyl-D-Aspartate Receptor Encephalitis.

Samantha Epstein, Jyoti Ankam, Wendy S Vargas, Kiran T Thakur

Open access · greenAbstract readCase Reports
In one paragraph

Article in The Neurohospitalist, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Samantha EpsteinDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, USA.ORCID https://orcid.org/0000-0003-1158-5430
Jyoti AnkamDepartment of Biostatistics and Advanced Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.
Wendy S VargasDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Kiran T ThakurDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, USA.ORCID https://orcid.org/0000-0003-0050-0323
Columbia University Irving Medical Center · USColumbia University · US

Funding

Innovative PK/PD Approaches to Optimize TBM Treatment in Children (PATCH Study)R01HD074944 · NICHD · JOHNS HOPKINS UNIVERSITY · PI DOOLEY, KELLY E. · 2014 to 2019
$2.5M
Clinical Impact of Early Pathogen Identification in Acute Neurological InfectionsK23NS105935 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI THAKUR, KIRAN TERESA · 2018 to 2022
$930k
NICHD NIH HHS R01 HD074944NINDS NIH HHS K23 NS105935
6 · The paper itself

Abstract

Infections are increasingly recognized as a common trigger of autoimmune disease, including autoimmune encephalitis. A significant association is particularly shown between HSV-1 encephalitis (HSVE) and a post-infectious autoimmune encephalitis mediated by neuronal autoantibodies, most notably anti-N-methyl-D-aspartate receptor (NMDAR) antibodies. The clinical significance of these and other novel post-infectious autoantibodies has led to new diagnostic and treatment challenges for clinicians. Here we present a case of a 19-year-old female with premorbid psychiatric disease and neuropsychiatric sequelae from HSVE who presented over a year after her initial HSVE with behavioral changes and positive anti-NMDAR antibodies. The clinical challenges encountered during this case are explored in detail based on a review of the literature. Research is needed to help guide management in these complex clinical situations.

Indexed as

autoimmune diseases of the nervous systemcentral nervous system infectionscentral nervous system viral diseasesclinical specialtyencephalitisneuroimmunology

Identifiers

PMID33791062
PMCPMC7958680
OpenAlexW3092282723

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.