Evidence map›Paper›PMID 33791043›Full record

ArticleDisease markers2021

Anti-inflammatory Effects of Alcohol Are Associated with JNK-STAT3 Downregulation in an

Katharina Mörs, Ramona Sturm, Jason-Alexander Hörauf, Shinwan Kany, Paola Cavalli, Jazan Omari, Maciej Powerski, Alexey Surov, Ingo Marzi, Aleksander J Nowak and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Disease markers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Serum HMGB1 and Alcohol-Related Liver Disease.Journal of clinical medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Katharina MörsDepartment of Trauma, Hand and Reconstructive Surgery, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
Ramona SturmDepartment of Trauma, Hand and Reconstructive Surgery, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
Jason-Alexander HöraufDepartment of Trauma, Hand and Reconstructive Surgery, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
Shinwan KanyDepartment of Cardiology with Emphasis on Electrophysiology, University Heart Centre, University Hospital Hamburg-Eppendorf, 20251 Hamburg, Germany.
Paola CavalliExperimental Radiology, Department of Radiology and Nuclear Medicine, Otto von Guericke University, Magdeburg, Germany.
Jazan OmariExperimental Radiology, Department of Radiology and Nuclear Medicine, Otto von Guericke University, Magdeburg, Germany.
Maciej PowerskiExperimental Radiology, Department of Radiology and Nuclear Medicine, Otto von Guericke University, Magdeburg, Germany.
Alexey SurovExperimental Radiology, Department of Radiology and Nuclear Medicine, Otto von Guericke University, Magdeburg, Germany.
Ingo MarziDepartment of Trauma, Hand and Reconstructive Surgery, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
Aleksander J NowakExperimental Radiology, Department of Radiology and Nuclear Medicine, Otto von Guericke University, Magdeburg, Germany.ORCID https://orcid.org/0000-0001-7069-8051
Borna ReljaDepartment of Trauma, Hand and Reconstructive Surgery, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.ORCID https://orcid.org/0000-0002-5625-8823
Goethe University Frankfurt · DEOtto-von-Guericke-Universität Magdeburg · DEUniversität Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn several preclinical and

methodsHepG2 cells were stimulated with IL-1

resultsIn this experimental design, EtOH did not markedly change the cell viability. Acute and prolonged exposure to EtOH significantly reduced dose-independent IL-1

conclusionEtOH exerts anti-inflammatory potential in this

Indexed as

Anti-Inflammatory AgentsCell AdhesionCell SurvivalDown-RegulationEthanolHep G2 CellsHumansIntercellular Adhesion Molecule-1Interleukin-6MAP Kinase Kinase 4NeutrophilsSignal TransductionSTAT3 Transcription FactorTumor Necrosis Factor-alphaAnti-Inflammatory AgentsEthanolIntercellular Adhesion Molecule-1Interleukin-6MAP Kinase Kinase 4STAT3 protein, humanSTAT3 Transcription FactorTumor Necrosis Factor-alpha

Identifiers

PMID33791043
PMCPMC7997757
OpenAlexW3136860849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.