ArticleNature physics2019
Large and reversible myosin-dependent forces in rigidity sensing.
Article in Nature physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Submicron traction-force mapping reveals mitochondrial regulation of nanoscale force coordination during rigidity sensing under oxidative stress.Nano convergence · 2026Article
- TiOAdvanced materials (Deerfield Beach, Fla.) · 2024Article
- A modified motor-clutch model reveals that neuronal growth cones respond faster to soft substrates.Molecular biology of the cell · 2024Article
- Contractility defects hinder glycoprotein VI-mediated platelet activation and affect platelet functions beyond clot contraction.Research and practice in thrombosis and haemostasis · 2024Article
- From stress fiber to focal adhesion: a role of actin crosslinkers in force transmission.Frontiers in cell and developmental biology · 2024Review
- Intrinsic self-organization of integrin nanoclusters within focal adhesions is required for cellular mechanotransduction.bioRxiv : the preprint server for biology · 2023Article
- Article
- Measuring Cytoskeletal Mechanical Fluctuations and Rheology with Active Micropost Arrays.Current protocols · 2022Article
- Biophysical Approaches for Applying and Measuring Biological Forces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Cancer cells can be killed mechanically or with combinations of cytoskeletal inhibitors.Frontiers in pharmacology · 2022Review
- Effects of forces on chromatin.APL bioengineering · 2021Review
- Quantitative developmental biology in vitro using micropatterning.Development (Cambridge, England) · 2021Review
- Extracellular Matrix Rigidity Modulates Human Cervical Smooth Muscle Contractility-New Insights into Premature Cervical Failure and Spontaneous Preterm Birth.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Collagen, stiffness, and adhesion: the evolutionary basis of vertebrate mechanobiology.Molecular biology of the cell · 2020Review
- RETRACTED: Human sperm uses asymmetric and anisotropic flagellar controls to regulate swimming symmetry and cell steering.Science advances · 2020Article
- Cellular contractile forces are nonmechanosensitive.Science advances · 2020Article
- Dissecting fat-tailed fluctuations in the cytoskeleton with active micropost arrays.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Cells sense the rigidity of their environment through localized pinching, which occurs when myosin molecular motors generate contractions within actin filaments anchoring the cell to its surroundings. We present high-resolution experiments performed on these elementary contractile units in cells. Our experimental results challenge the current understanding of molecular motor force generation. Surprisingly, bipolar myosin filaments generate much larger forces per motor than measured in single molecule experiments. Further, contraction to a fixed distance, followed by relaxation at the same rate, is observed over a wide range of matrix rigidities. Lastly, step-wise displacements of the matrix contacts are apparent during both contraction and relaxation. Building upon a generic two-state model of molecular motor collections, we interpret these unexpected observations as spontaneously emerging features of a collective motor behavior. Our approach explains why, in the cellular context, collections of resilient and slow motors contract in a stepwise fashion while collections of weak and fast motors do not. We thus rationalize the specificity of motor contractions implied in rigidity sensing compared to previous in vitro observations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.