Evidence map›Paper›PMID 33790886›Full record

ArticleFrontiers in immunology2021

Specific Host Signatures for the Detection of Tuberculosis Infection in Children in a Low TB Incidence Country.

Alexandra Dreesman, Véronique Corbière, Myriam Libin, Judith Racapé, Philippe Collart, Mahavir Singh, Camille Locht, Françoise Mascart, Violette Dirix

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Alexandra DreesmanLaboratory of Vaccinology and Mucosal Immunity, Université Libre de Bruxelles, Brussels, Belgium.
Véronique CorbièreLaboratory of Vaccinology and Mucosal Immunity, Université Libre de Bruxelles, Brussels, Belgium.
Myriam LibinLaboratory of Vaccinology and Mucosal Immunity, Université Libre de Bruxelles, Brussels, Belgium.
Judith RacapéBiomedical Research Center, Erasme Hospital, Brussels, Belgium.
Philippe CollartCentre de recherche Epidémiologie, Biostatistiques, Recherche Clinique, School of Public Health, Université Libre de Bruxelles, Brussels, Belgium.
Mahavir SinghLionex Diagnostics and Therapeutics, Braunschweig, Germany.
Camille LochtUniv. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR9017 - CIIL - Center for Infection and Immunity of Lille, Lille, France.
Françoise MascartLaboratory of Vaccinology and Mucosal Immunity, Université Libre de Bruxelles, Brussels, Belgium.
Violette DirixLaboratory of Vaccinology and Mucosal Immunity, Université Libre de Bruxelles, Brussels, Belgium.
Université Libre de Bruxelles · BECentre Hospitalier Universitaire de Lille · FRLionex (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diagnosis of tuberculosis (TB) in children remains challenging due to unspecific clinical presentation and low bacillary load. In low TB incidence countries, most cases are diagnosed by a contact screening strategy after exposure to an index TB case. Due to the severity of TB in young children, the priority is to determine whether a child is infected or not, whereas differential diagnosis between active TB (aTB) and latent TB constitutes a second step. In Belgium, a low TB incidence country, we prospectively included 47 children with a defined

Indexed as

AdolescentBelgiumCells, CulturedChildChild, PreschoolCytokinesFemaleHost-Pathogen InteractionsHumansIncidenceInfantInfant, NewbornLatent TuberculosisMaleMycobacterium tuberculosisT-LymphocytesCytokinesculture-filtrate-protein-10heparin-binding haemagglutininInterferon-γinterferon-γ-induced protein 10purified-protein derivativetuberculosistumor-necrosis-factor-α

Identifiers

PMID33790886
PMCPMC8005539
OpenAlexW3138489987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.