ArticleFrontiers in endocrinology2021
Low Prognosis by the POSEIDON Criteria in Women Undergoing Assisted Reproductive Technology: A Multicenter and Multinational Prevalence Study of Over 13,000 Patients.
Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Male Factor Infertility Across India: An Observational Cross-Sectional Study Using the Aphrodite Criteria, a Hospital-based Study
"Gonadotropin Therapy in Idiopathic Hypogonadal Non-Obstructive Azoospermia (APHRODITE Groups 3-4): A Multicenter Randomized Controlled Trial"
Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Frozen versus fresh embryo transfer in women with low prognosis for in vitro fertilisation treatment: pragmatic, multicentre, randomised controlled trial.BMJ (Clinical research ed.) · 2025Trial
- Efficacy and safety of Shen Que (RN8) moxibustion on reproductive outcomes in unexpected poor ovarian responders: a randomized controlled trial.Journal of ovarian research · 2024Trial
- The impact of resveratrol on the outcome of the in vitro fertilization: an exploratory randomized placebo-controlled trial.Journal of ovarian research · 2024Trial
- Cleavage stage versus blastocyst stage transfers in patients with a single zygote: an emulated target trial.Human reproduction (Oxford, England) · 2026Article
- Comparing clinical outcomes of rFSH versus rFSH+HP-hMG in women undergoing in vitro fertilization-embryo transfer in real‑world practice: a retrospective study.Scientific reports · 2026Article
- Medium-sized follicle proportion on the trigger day may be associated with higher live birth rate in fresh embryo transfer cycles among low-prognosis patients: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Unexpected hypo-responders in in vitro fertilization: The impact of higher gonadotropin doses on oocyte yield.Turkish journal of obstetrics and gynecology · 2025Article
- Effects of maternal poor ovarian response on the reproductive endocrine profiles of the next generation: a prospective cohort study in China.Human reproduction open · 2025Article
- Analysis of factors associated with IVF/ICSI clinical outcomes in advanced maternal age patients with normal ovarian reserve under the POSEIDON criteria.Frontiers in endocrinology · 2025Article
- Gonadotropin dose selection for repeat IVF cycles in POSEIDON Groups 1 and 2.Frontiers in endocrinology · 2025Article
- Development and validation of a nomogram for failure to collect oocytes in POSEIDON Groups 3 and 4 undergoing IVF/ICSI treatment.Scientific reports · 2024Article
- Effect of follicle-stimulating hormone dose on the risk of being classified as suboptimal responders according to the POSEIDON criteria.Journal of assisted reproduction and genetics · 2024Article
- Patients with low prognosis in ART: a Delphi consensus to identify potential clinical implications and measure the impact of POSEIDON criteria.Reproductive biology and endocrinology : RB&E · 2024Article
- Do we overlook predictive factors in Poseidon 1 patients? A retrospective analysis co-evaluating antral follicle counts & diameters.Journal of ovarian research · 2024Article
- Follicular versus luteal stimulation in suboptimal responders: Maybe timing isn't everything?F&S reports · 2023Article
- Article
- Luteal Phase Stimulation in the Same Cycle Is an Effective Strategy to Rescue POSEIDON Poor Responders with No Embryos after the First Follicular Stimulation.Journal of human reproductive sciencesArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To estimate the prevalence of low-prognosis patients according to the POSEIDON criteria using real-world data. Design: Multicenter population-based cohort study. Settings: Fertility clinics in Brazil, Turkey, and Vietnam. Patients: Infertile women undergoing assisted reproductive technology using standard ovarian stimulation with exogenous gonadotropins. Interventions: None. Main outcome measures: Per-period prevalence rates of POSEIDON patients (overall, stratified by POSEIDON groups and by study center) and the effect of covariates on the probability that a patient be classified as "POSEIDON". Results: A total of 13,146 patients were included. POSEIDON patients represented 43.0% (95% confidence interval [CI] 42.0-43.7) of the studied population, and the prevalence rates varied across study centers (range: 38.6-55.7%). The overall prevalence rates by POSEIDON groups were 44.2% (group 1; 95% CI 42.6-45.9), 36.1% (group 2; 95% CI 34.6-37.7), 5.2% (group 3; 95% CI 4.5-6.0), and 14.4% (group 4; 95% CI: 13.3-15.6). In general, POSEIDON patients were older, had a higher body mass index (BMI), lower ovarian reserve markers, and a higher frequency of female factor as the primary treatment indication than non-POSEIDON patients. The former required larger doses of gonadotropin for ovarian stimulation, despite achieving a 2.5 times lower number of retrieved oocytes than non-POSEIDON patients. Logistic regression analyses revealed that female age, BMI, ovarian reserve, and a female infertility factor were relevant predictors of the POSEIDON condition. Conclusions: The estimated prevalence of POSEIDON patients in the general population undergoing ART is significant. These patients differ in clinical characteristics compared with non-POSEIDON patients. The POSEIDON condition is associated with female age, ovarian reserve, BMI, and female infertility. Efforts in terms of diagnosis, counseling, and treatment are needed to reduce the prevalence of low-prognosis patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.