ArticleFrontiers in human neuroscience2021
Brain Development From Newborn to Adolescence: Evaluation by Neurite Orientation Dispersion and Density Imaging.
Article in Frontiers in human neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Automated Surface-Based Segmentation of Deep Gray Matter Regions Based on Diffusion Tensor Images Reveals Unique Age Trajectories Over the Healthy Lifespan.NMR in biomedicine · 2026Article
- Multiscale brain development across the human lifespan.Communications biology · 2026Review
- Highly replicable multisite patterns of adolescent white matter maturation.bioRxiv : the preprint server for biology · 2026Article
- Neurodevelopmental disorders in children: the role of MRI in early detection and intervention planning.Frontiers in neuroscience · 2026Review
- Article
- The promise of infant MRI in psychiatry: toward a framework for neural network measures in early emotional and behavioral risk identification and new intervention targets.Molecular psychiatry · 2026Review
- Cerebral microstructural alteration patterns in motor subtypes of Parkinson's disease: a neurite orientation dispersion and density imaging study.Quantitative imaging in medicine and surgery · 2025Article
- Advanced Quantitative Microstructure Imaging in Autism: A Review of Methodology, Group Differences, and Associations With Developmental Outcomes.Autism research : official journal of the International Society for Autism Research · 2025Review
- The Impact of Early Life Exposure to Air Pollution on the Brain: A Diffusion MRI Study in 10-13-Year-Old Children With and Without ADHD Diagnosis.Human brain mapping · 2025Article
- In vivo mapping of infant brain microstructure with neurite orientation dispersion and density imaging.Brain structure & function · 2025Review
- Microstructural Characterization of Short Association Fibers Related to Long-Range White Matter Tracts in Normative Development.Human brain mapping · 2025Article
- Decoding Brain Development and Aging: Pioneering Insights From MRI Techniques.Investigative radiology · 2025Review
- White Matter Differences in Early-Stage Alcohol Use Disorder: Diffusion Tensor and Neurite Orientation Dispersion and Density Measures of Structural Integrity.Addiction biology · 2025Article
- Neurite development varies across the hippocampus and covaries with the cellular composition of hippocampal tissue.Communications biology · 2025Article
- Brain white matter development in 8-year-old children is associated with maternal mental health during pregnancy.Frontiers in human neuroscience · 2025Article
- High-resolution diffusion magnetic resonance imaging and spatial-transcriptomic in developing mouse brain.NeuroImage · 2024Article
- Neurite density of the hippocampus is associated with trace eyeblink conditioning latency in 4- to 6-year-olds.The European journal of neuroscience · 2024Article
- Spatiotemporal patterns of cortical microstructural maturation in children and adolescents with diffusion MRI.Human brain mapping · 2024Article
- White matter tract microstructure, macrostructure, and associated cortical gray matter morphology across the lifespan.bioRxiv : the preprint server for biology · 2023Article
- Premature white matter microstructure in female children with a history of concussion.Developmental cognitive neuroscience · 2023Article
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9 authors.
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Abstract
Neurite orientation dispersion and density imaging (NODDI) is a diffusion model specifically designed for brain magnetic resonance imaging. Despite recent studies suggesting that NODDI modeling might be more sensitive to brain development than diffusion tensor imaging (DTI), these studies were limited to a relatively small age range and mainly based on the manually operated region of interest analysis. Therefore, this study applied NODDI to investigate brain development in a large sample size of 214 subjects ranging in ages from 0 to 14. The whole brain was automatically segmented into 122 regions. The maturation trajectory of each region was characterized by the time course of diffusion metrics and further quantified using nonlinear regression. The NODDI-derived metrics, neurite density index (NDI) and orientation dispersion index (ODI), increased with age. And these two metrics were superior to the DTI-derived metrics in SVM regression models of age. The NDI in white matter exhibited a more rapid growth than that in gray matter (including the cortex and deep nucleus). These diffusion indicators experienced conspicuous increases during early childhood and the growth speed slowed down in adolescence. Region-specific maturation patterns were described throughout the brain, including white matter, cortical and deep gray matter. These development patterns were evaluated and discussed on the basis of NODDI's model assumptions. To summarize, this study verified the high sensitivity of NODDI to age over a crucial developmental period from newborn to adolescence. Moreover, the existing knowledge of brain development has been complemented, suggesting that NODDI has a potential capability in the investigation of brain development.
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