Evidence map›Paper›PMID 33790542›Full record

ArticleDrug design, development and therapy2021

N

Ahmed M Naglah, Gaber O Moustafa, Ahmed A Elhenawy, Marwa M Mounier, Heba El-Sayed, Mohamed A Al-Omar, Abdulrahman A Almehizia, Mashooq A Bhat

Open access · goldAbstract read
In one paragraph

Article in Drug design, development and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Ahmed M NaglahDepartment of Pharmaceutical Chemistry, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia.ORCID 0000-0003-4377-5239
Gaber O MoustafaPeptide Chemistry Department, Chemical Industries Research Division, National Research Centre, Cairo, Egypt.ORCID 0000-0002-2489-8228
Ahmed A ElhenawyChemistry Department, Faculty of Science, Al-Azhar University (Boys'Branch), Cairo, Egypt.ORCID 0000-0003-2893-0376
Marwa M MounierPharmacognosy Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Giza, Egypt.ORCID 0000-0003-1584-9245
Heba El-SayedBotany and Microbiology Department, Faculty of Science, Helwan University, Helwan, Egypt.ORCID 0000-0003-2962-6755
Mohamed A Al-OmarDepartment of Pharmaceutical Chemistry, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia.ORCID 0000-0002-9866-343X
Abdulrahman A AlmehiziaDepartment of Pharmaceutical Chemistry, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia.ORCID 0000-0001-8711-3873
Mashooq A BhatDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia.ORCID 0000-0001-8426-4692
King Saud University · SANational Research Centre · EGAl-Azhar University · EGHelwan University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe objective of our work was to prepare a potent and safe antimicrobial and anticancer agents, through synthesis of several peptides and examine their biological activities, namely as, cytotoxically potent and antimicrobial and antifungal agents.

introductionMultidrug-resistant microbial strains have arisen against all antibiotics in clinical use. Infections caused by these bacteria threaten global public health and are associated with high mortality rates.

methodsThe main backbone structure for the novel synthesized linear peptide is Nα-1, 3-benzenedicarbonyl-bis-(Amino acids)-X, (

resultsThe peptide-bearing methionine-ester (

conclusionThe tested compounds need further modification to have significant antimicrobial and antitumor efficacy compared to the reference drugs.

Indexed as

Molecular Docking SimulationAmino AcidsAnti-Bacterial AgentsAntifungal AgentsAntineoplastic AgentsCell Line, TumorCell ProliferationCell SurvivalDipeptidesDrug Screening Assays, AntitumorGram-Negative BacteriaGram-Positive BacteriaHumansMicrobial Sensitivity TestsAmino AcidsAnti-Bacterial AgentsAntifungal AgentsAntineoplastic AgentsDipeptides3-benzenedicarbonyl-bis-peptidesanticancerantimicrobial activitylinear-peptidesmolecular dockingNα-1

Identifiers

PMID33790542
PMCPMC8006965
OpenAlexW3148796613

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.