ArticleNature2021
Structural basis of malaria RIFIN binding by LILRB1-containing antibodies.
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In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Molecular basis of fibrinogen recognition by the innate immune receptor LILRA2.The Journal of biological chemistry · 2026Article
- Inhibitory NK receptor expression associates with altered antimalarial function of γδ T cells.PLoS pathogens · 2026Article
- Altered natural killer cell function in children with severe malaria.ImmunoHorizons · 2026Article
- A subset of Plasmodium falciparum RIFINs is linked to severe malaria risk reduction and engages LILRB1 through a conserved structural motif.EBioMedicine · 2025Article
- A strategy for the development of receptor-containing antibodies targeting malaria variant surface antigens.Science China. Life sciences · 2025Article
- Article
- Diamonds in the rif: Alignment-free comparative genomics analysis reveals strain-transcendent Plasmodium falciparum antigens amidst extensive genetic diversity.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2025Article
- Inhibitory leukocyte immunoglobulin-like receptors, subfamily B (LILRBs) in human diseases: structure, roles, mechanisms, and clinical applications.Theranostics · 2025Review
- A new mechanism of antibody diversity: formation of the natural antibodies containing LAIR1 and LILRB1 extracellular domains.Antibody therapeutics · 2024Review
- Variable Surface Antigens ofProtein and peptide letters · 2024Review
- High-Throughput Antibody Profiling Identifies Targets of Protective Immunity againstBiomolecules · 2023Article
- Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria.Science translational medicine · 2023Article
- Different classes of genomic inserts contribute to human antibody diversity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Somatic Diversification of Rearranged Antibody Gene Segments by Intra- and Interchromosomal Templated Mutagenesis.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Trapezoid-kinoform zone plate lens - a solution for efficient focusing in hard X-ray optics.Journal of synchrotron radiation · 2022Article
- Mechanisms for Host Immune Evasion Mediated byFrontiers in immunology · 2022Review
- Immunoglobulin germline gene variation and its impact on human disease.Genes and immunity · 2021Review
- Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs.Nature communications · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 7 institutions in 2 countries.
Yiwei Chen *Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.ORCID http://orcid.org/0000-0003-3558-9954
Kai Xu *Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Luca PiccoliInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.ORCID http://orcid.org/0000-0002-1085-6502
Mathilde FoglieriniInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.ORCID http://orcid.org/0000-0001-7538-4262
Joshua TanInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.ORCID http://orcid.org/0000-0002-6661-6372
Wenjie JinInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.
Jason GormanVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-3775-6560
Yaroslav TsybovskyElectron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Baoshan ZhangVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Boubacar TraoreMalaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, International Center of Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
Chiara Silacci-FregniInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.
Claudia DaubenbergerSwiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland.
Peter D CromptonLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Roger GeigerInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.ORCID http://orcid.org/0000-0002-8016-1669
Federica SallustoInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.ORCID http://orcid.org/0000-0003-3750-2752
Peter D KwongVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-3560-232X
Antonio LanzavecchiaInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland. alanzavecchia@vir.bio.ORCID http://orcid.org/0000-0002-3041-7240
National Institutes of Health · USUniversità della Svizzera italiana · CHETH Zurich · CHLeidos (United States) · USSIB Swiss Institute of Bioinformatics · CHSwiss Tropical and Public Health Institute · CHVir Biotechnology (Switzerland) · CH
Funding
Mechanisms of naturally-acquired immunity to malaria and clinical trials of anti-malaria monoclonal antibodiesZIAAI001155 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CROMPTON, PETER · 2011 to 2025
$30.9MNeutralization Mechanisms Of Anti-HIV-1 Monoclonal AntibodiesZIAAI005022 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ZHOU, TONGQING · 2009 to 2025
$24.6MTRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7MCCR NIH HHS HHSN261200800001CEuropean Research Council 670955NCI NIH HHS HHSN261200800001ENIGMS NIH HHS P41 GM103310
Abstract
Some Plasmodium falciparum repetitive interspersed families of polypeptides (RIFINs)-variant surface antigens that are expressed on infected erythrocytes
Indexed as
Cryoelectron MicroscopyAdolescentAdultAmino Acid SequenceAntibodiesAntibody SpecificityAntigens, ProtozoanBinding Sites, AntibodyChildChild, PreschoolCohort StudiesHumansInfantLeukocyte Immunoglobulin-like Receptor B1MaliModels, MolecularAntibodiesAntigens, ProtozoanLeukocyte Immunoglobulin-like Receptor B1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.