ReviewNature reviews. Neuroscience2021
The self in context: brain systems linking mental and physical health.
Review in Nature reviews. Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
94 citing papers in PubMed, 3 syntheses or guidelines pooled it, 242 citations in OpenAlex.
- Systematic review and meta-analysis of psychological interventions for depression symptoms in young people with long-term physical health conditions.Journal of pediatric psychology · 2025Pooled it
- 2025 iCatCare consensus guidelines on the diagnosis and management of lower urinary tract diseases in cats.Journal of feline medicine and surgery · 2025Guideline
- Human neural correlates of emotional well-being (EWB): a preliminary systematic review and meta-analysis of MRI studies based on a recent consensus definition.Frontiers in human neuroscience · 2025Pooled it
- Prayer for Pain and Anxiety in a Primary Care Setting: A Randomized Controlled Trial.Annals of family medicine · 2026Trial
- Gastrointestinal Symptoms in Pediatric Patients with Anxiety Disorders and Their Relationship to Selective Serotonin Reuptake Inhibitor Treatment or Placebo.Child psychiatry and human development · 2025Trial
- Effects of compassion training on brain responses to suffering others.Social cognitive and affective neuroscience · 2021Trial
- Psycho-cardiovascular interaction network in cardiovascular health and disease: signaling pathways and molecular mechanisms.Precision clinical medicine · 2026Review
- The functional neurobiology of dispositions towards negative emotions.Nature communications · 2026Article
- Brain neuromarkers predict self- and other-related mentalizing across adult, clinical, and developmental samples.Nature communications · 2026Article
- Suicidality in women nurses: A critical interpretive synthesis.International journal of nursing studies advances · 2026Review
- Psychological Adjustment to Disease and Treatment: Commentary on Dekker (2024).Stress and health : journal of the International Society for the Investigation of Stress · 2026Article
- Latent neural architecture organising shared aesthetic evaluations of visual artworks.Nature communications · 2026Article
- Computer-Assisted Performance-Based Assessment for Mental Health: A Scoping Review.PsyCh journal · 2026Article
- Self-allocation bias in performance-based cooperative decisions is driven by self-interest rather than distorted performance encoding.PLoS biology · 2026Article
- Brain-immune correlates of quality of life in adolescents with chronic musculoskeletal pain.Brain, behavior, and immunity · 2026Article
- Affective schemas: Acquisition, updating, and inference.Emotion (Washington, D.C.) · 2026Article
- Comparison of Mental Illness Comorbidity Pre-Pandemic vs. Pandemic-Era and Associations with Clinical and Demographic Characteristics for Virginia Public Hospital Inpatient Discharges with a Substance Use Disorder.International journal of environmental research and public health · 2026Article
- Mindsets impact training adaptation and high-pressure performance: beliefs and perceptions of professionals working in elite sport and mission critical teams.Frontiers in sports and active living · 2026Article
- From mechanisms to meanings: toward a content-sensitive psychiatry.Frontiers in psychiatry · 2026Article
- Patient subtyping in juvenile fibromyalgia: the role of multisensory hypersensitivity and neurophysiological correlates.Journal of pediatric psychology · 2025Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
Abstract
Increasing evidence suggests that mental health and physical health are linked by neural systems that jointly regulate somatic physiology and high-level cognition. Key systems include the ventromedial prefrontal cortex and the related default-mode network. These systems help to construct models of the 'self-in-context', compressing information across time and sensory modalities into conceptions of the underlying causes of experience. Self-in-context models endow events with personal meaning and allow predictive control over behaviour and peripheral physiology, including autonomic, neuroendocrine and immune function. They guide learning from experience and the formation of narratives about the self and one's world. Disorders of mental and physical health, especially those with high co-occurrence and convergent alterations in the functionality of the ventromedial prefrontal cortex and the default-mode network, could benefit from interventions focused on understanding and shaping mindsets and beliefs about the self, illness and treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.