ArticlePediatric research2022
Patent ductus arteriosus, tracheal ventilation, and the risk of bronchopulmonary dysplasia.
Article in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Early treatment versus expectant management of hemodynamically significant patent ductus arteriosus for preterm infants.The Cochrane database of systematic reviews · 2025Pooled it
- Procedural closure of the patent ductus arteriosus in preterm infants: a clinical practice guideline.Journal of perinatology : official journal of the California Perinatal Association · 2024Guideline
- Burden and predictors of bronchopulmonary dysplasia in preterm infants: A seven-year cohort.Journal of Taibah University Medical Sciences · 2026Article
- Case Report: Comprehensive management of bedside ligation of patent ductus arteriosus in an extremely low birth weight infant.Frontiers in cardiovascular medicine · 2026Article
- Adding Early Postnatal Parameters of Ventilation to Prognostic Models for Pulmonary Outcome in Very Preterm Infants.Pediatric pulmonology · 2025Article
- Correlation analysis between patent ductus arteriosus and bronchopulmonary dysplasia in premature infants.Italian journal of pediatrics · 2025Article
- The pathogenesis of bronchopulmonary dysplasia: "It is never the heart, it is always the lung" - myth or maxim?Breathe (Sheffield, England) · 2025Review
- Characteristics of neonatal necrotizing enterocolitis in relation to the presence or absence of patent ductus arteriosus.BMC pregnancy and childbirth · 2025Article
- Respiratory Outcomes After Transcatheter vs Surgical Patent Ductus Arteriosus Closure in Preterm Infants.JAMA network open · 2025Article
- A Discourse on Percutaneous Closure of the Patent Ductus Arteriosus in Premature Neonates: Controversy, Remedy, or Paradox of Choice?CJC pediatric and congenital heart disease · 2025Review
- The Effect on Extubation of Early vs. Late Definitive Closure of the Patent Ductus Arteriosus in Premature Infants: A Target Trial Emulation Using Electronic Health Records.Journal of clinical medicine · 2025Article
- Transcatheter patent ductus arteriosus closure in very low birth weight preterm infants: early results and midterm follow-up.Frontiers in pediatrics · 2025Article
- Analysis of risk factors contributing to neonatal pneumonia in low birth weight neonates.Frontiers in pediatrics · 2025Article
- Article
- Association between patent ductus arteriosus flow and home oxygen therapy in extremely preterm infants.Pediatric research · 2024Article
- Patent Ductus Arteriosus and Development of Bronchopulmonary Dysplasia-associated Pulmonary Hypertension.American journal of respiratory and critical care medicine · 2023Article
- Predictors of Bronchopulmonary Dysplasia in Infants With Birth Weight Less Than 1500 g.Global pediatric health · 2023Article
- Conservative Management of Patent Ductus Arteriosus Is Feasible in the Peri-Viable Infants at 22-25 Gestational Weeks.Biomedicines · 2022Article
- Effects of prophylactic indomethacin on morbidity and mortality in infants <25 weeks' gestation: a protocol driven intention to treat analysis.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- An Update on Patent Ductus Arteriosus and What is Coming Next.Turkish archives of pediatrics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 10 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn increased risk for bronchopulmonary dysplasia (BPD) exists when moderate-to-large patent ductus arteriosus shunts (hsPDA) persist beyond 14 days. GOAL: To examine the interaction between prolonged exposures to tracheal ventilation (≥10 days) and hsPDA on the incidence of BPD in infants <28 weeks gestation. STUDY
designPredefined definitions of prolonged ventilation (≥10 days), hsPDA (≥14 days), and BPD (room air challenge test at 36 weeks) were used to analyze deidentified data from the multicenter TRIOCAPI RCT in a secondary analysis of the trial.
resultsAmong 307 infants who survived >14 days, 41 died before 36 weeks. Among survivors, 93/266 had BPD. The association between BPD and hsPDA depended on the length of intubation. In multivariable analyses, prolonged hsPDA shunts were associated with increased BPD (odds ratio (OR) (95% confidence interval (CI)) = 3.00 (1.58-5.71)) when infants required intubation for ≥10 days. In contrast, there was no significant association between hsPDA exposure and BPD when infants were intubated <10 days (OR (95% CI) = 1.49 (0.98-2.26)). A similar relationship between prolonged hsPDA and length of intubation was found for BPD/death (n = 307): infants intubated ≥10 days: OR (95% CI) = 2.41 (1.47-3.95)); infants intubated <10 days: OR (95% CI) = 1.37 (0.86-2.19)).
conclusionsModerate-to-large PDAs were associated with increased risks of BPD and BPD/death-but only when infants required intubation ≥10 days. IMPACT: Infants with a moderate-to-large hsPDA that persist beyond 14 days are only at risk for developing BPD if they also receive prolonged tracheal ventilation for ≥10 days. Infants who receive less ventilatory support (intubation for <10 days) have the same incidence of BPD whether the ductus closes shortly after birth or whether it persists as a moderate-to-large shunt for several weeks. Early PDA closure may be unnecessary in infants who require short durations of intubation since the PDA does not seem to alter the incidence of BPD in infants who require intubation for <10 days.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.