Evidence map›Paper›PMID 33790398›Full record

ArticleEuropean journal of clinical nutrition2022

Associations of early nutrition with growth and body composition in very preterm infants: a prospective cohort study.

Junyan Han, Lan Zhang, Shujuan Li, Yi Zhang, Yuan Jiang, Xiaotian Chen, Yin Wang, Yalan Dou, Ping Dong, Yujing Lv and 2 more

Abstract read
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In one paragraph

Article in European journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Defining growth faltering and malnutrition among very preterm infants in a neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Junyan HanDepartment of Clinical Epidemiology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.ORCID http://orcid.org/0000-0002-6761-9356
Lan ZhangDepartment of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.ORCID http://orcid.org/0000-0002-1983-9928
Shujuan LiDepartment of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.ORCID http://orcid.org/0000-0001-8877-9394
Yi ZhangDepartment of Clinical Epidemiology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.ORCID http://orcid.org/0000-0001-9142-974X
Yuan JiangDepartment of Clinical Epidemiology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.ORCID http://orcid.org/0000-0002-4542-9578
Xiaotian ChenDepartment of Clinical Epidemiology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.ORCID http://orcid.org/0000-0001-9520-7060
Yin WangDepartment of Clinical Epidemiology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.ORCID http://orcid.org/0000-0002-4491-7465
Yalan DouDepartment of Clinical Epidemiology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.ORCID http://orcid.org/0000-0002-4414-4730
Ping DongDepartment of Child Healthcare, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.ORCID http://orcid.org/0000-0001-8670-7557
Yujing LvDepartment of Child Healthcare, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.ORCID http://orcid.org/0000-0002-4593-2181
Yun Cao *Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China. yuncao@fudan.edu.cn.ORCID http://orcid.org/0000-0002-3266-0308
Weili Yan *Department of Clinical Epidemiology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China. yanwl@fudan.edu.cn.ORCID http://orcid.org/0000-0002-7633-7449
Children's Hospital of Fudan University · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectiveTo investigate impacts of early postnatal macronutrient intakes on growth and body composition of preterm infants within the first 6 months. SUBJECTS/

methodsOne hundred and thirty-three very preterm (VPT) and/or very low birth weight (VLBW) infants were consecutively included. Enteral and parenteral macronutrient intakes during the first 28 days were recorded and average daily intakes were calculated. Growth was measured at birth, term age, and 6 months of corrected age (CA). Body composition was examined by air displacement plethysmograph at term age and 6 months of CA. Associations of nutrient intakes with growth and body composition over time were analyzed using generalized estimating equation.

resultsAfter adjusting for covariates, higher daily protein, lipid, and energy intake during the first 28 days was associated with higher weight at term age for every 1 g/kg/day increment of protein and lipid intake, and every 10 kcal/kg/day increment of energy intake was associated with 0.50 (95% CI 0.04, 0.96), 0.29 (95% CI 0.07, 0.51), and 0.27 (95% CI 0.10, 0.44) higher weight z-score, respectively. Higher protein intake was associated with lower z-score of fat mass (FM, β = -1.88, 95% CI -3.53, -0.23) and percentage of body fat (PBF, β = -2.18, 95% CI -3.98, -0.39) at 6 months of CA, but higher lipid and carbohydrate intake was associated with higher FM and PBF z-scores at 6 months of CA.

conclusionsMacronutrient intakes during the first month of life have impacts on growth and body composition before 6 months of age. Higher daily protein intake is associated with a better growth and healthier body composition for VPT/VLBW infants.

Indexed as

Infant, PrematureNutritional StatusBody CompositionEnergy IntakeHumansInfantInfant, NewbornInfant Nutritional Physiological PhenomenaInfant, Very Low Birth WeightProspective Studies

Identifiers

PMID33790398
OpenAlexW3140673023

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.