ArticleScientific reports2021
A primitive type of renin-expressing lymphocyte protects the organism against infections.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Bright Cells, and Inefficient Enzymatic Activity in a Renin Hypomorph Mouse.bioRxiv : the preprint server for biology · 2025Article
- Piezo channels in JG cells do not regulate renin expression or renin release to the circulation.Clinical science (London, England : 1979) · 2024Article
- An efficient inducible model for the control of gene expression in renin cells.American journal of physiology. Renal physiology · 2024Article
- Elusive and Heterogenous Nature of Renin Cells.Hypertension (Dallas, Tex. : 1979) · 2024Article
- A novel multiplex biomarker panel for profiling human acute and chronic kidney disease.Scientific reports · 2023Article
- Overexpression of notch signaling in renin cells leads to a polycystic kidney phenotype.Clinical science (London, England : 1979) · 2023Article
- Organ-specific host differential gene expression analysis in systemic candidiasis: A systems biology approach.Microbial pathogenesis · 2022Article
- The emerging roles and therapeutic potential of B cells in sepsis.Frontiers in pharmacology · 2022Review
- Renin Cells, the Kidney, and Hypertension.Circulation research · 2021Review
- Deciphering the Identity of Renin Cells in Health and Disease.Trends in molecular medicine · 2021Review
- Ctcf is required for renin expression and maintenance of the structural integrity of the kidney.Clinical science (London, England : 1979) · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The hormone renin plays a crucial role in the regulation of blood pressure and fluid-electrolyte homeostasis. Normally, renin is synthesized by juxtaglomerular (JG) cells, a specialized group of myoepithelial cells located near the entrance to the kidney glomeruli. In response to low blood pressure and/or a decrease in extracellular fluid volume (as it occurs during dehydration, hypotension, or septic shock) JG cells respond by releasing renin to the circulation to reestablish homeostasis. Interestingly, renin-expressing cells also exist outside of the kidney, where their function has remained a mystery. We discovered a unique type of renin-expressing B-1 lymphocyte that may have unrecognized roles in defending the organism against infections. These cells synthesize renin, entrap and phagocyte bacteria and control bacterial growth. The ability of renin-bearing lymphocytes to control infections-which is enhanced by the presence of renin-adds a novel, previously unsuspected dimension to the defense role of renin-expressing cells, linking the endocrine control of circulatory homeostasis with the immune control of infections to ensure survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.