Observational studyScientific reports2021
Trends in the incidence and mortality of legionellosis in Japan: a nationwide observational study, 1999-2017.
Observational study in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Seroprevalence of Antibodies Against Legionella Species in Northeastern Australian Blood Donors, 2016 and 2023.The Journal of infectious diseases · 2026Article
- Evolution and main causes of the rising legionellosis incidence in the United States.PLOS global public health · 2026Article
- Seasonal Dynamics and Legionellosis-Associated Hospitalization in Spain: A Retrospective Study.Pathogens (Basel, Switzerland) · 2025Article
- Physicians' degree of awareness regarding the risks, clinical practices, and management challenges of nosocomial legionnaires' disease: A cross-sectional study from two Ethiopian hospitals.SAGE open medicine · 2025Article
- IL-1beta expressing neutrophil extracellular traps inFrontiers in immunology · 2025Article
- Daily diurnal temperature range associated with emergency ambulance calls: a nine-year time-series study.Frontiers in public health · 2024Article
- Sex and gender differences in intensive care medicine.Intensive care medicine · 2023Review
- Impact of the COVID-19 pandemic on the epidemiology of other communicable diseases in Japan.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023Article
- Incidence and risk factors associated with progression to severe pneumonia among adults with non-severe Legionella pneumonia.Acute and critical care · 2022Article
- Sex and Gender Differences in Bacterial Infections.Infection and immunity · 2022Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examined temporal trend, seasonality, and geographical variations of legionellosis incidence and mortality in Japan. This nationwide observational study used the Japanese Vital Statistics and Infectious Diseases Weekly Report (1999-2017) data to calculate legionellosis crude and age-adjusted incidence and mortality rates per 100,000 population by age and sex. Incidence was compared among the 4 seasons and regional incidence among 47 prefectures. Of 13,613 (11,194 men) people with legionellosis in Japan, 725 (569 men) were fatal. Increasing incidence trend occurred from 0.0004 (1999) to 1.37 (2017) per 100,000 population. People aged ≥ 70 years accounted for 43.1% overall; men's age-adjusted incidence rate was consistently approximately five times higher than for women. Significantly higher incidence occurred in summer than in winter (p = 0.013). Geographically, highest incidence (≥ 2.0 per 100,000 population) occurred in Hokuriku District, with increasing trends in Hokkaido and middle-part of Japan. Estimated fatality rates decreased consistently at 5.9% (95% confidence interval: - 8.1, - 3.5) annually, from 1999 to 2017, with no trend change point. Increasing legionellosis incidence occurred in Japan during 1999-2017, with declining estimated fatality rates. In this aging society and warming world, disease clinical burden may further deteriorate in future due to increasing incidence trends.
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