Evidence map›Paper›PMID 33790291›Full record

ArticleNature communications2021

Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism.

Christopher R Horne, Hariprasad Venugopal, Santosh Panjikar, David M Wood, Amy Henrickson, Emre Brookes, Rachel A North, James M Murphy, Rosmarie Friemann, Michael D W Griffin and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
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  15. Metabolic engineering ofSynthetic and systems biotechnology · 2023
    Article
  16. Article
  17. Article
  18. Review
  19. Bacterial Sialic Acid Catabolism at the Host-Microbe Interface.Journal of microbiology (Seoul, Korea) · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 5 countries.

Christopher R Horne *Biomolecular Interaction Centre and School of Biological Sciences, University of Canterbury, Christchurch, New Zealand.ORCID 0000-0003-1318-514X
Hariprasad Venugopal *Clive and Vera Ramaciotti Centre for Cryo-Electron Microscopy, Monash University, Clayton, VIC, Australia.
Santosh PanjikarAustralian Synchrotron, ANSTO, Clayton, VIC, Australia.ORCID 0000-0001-7429-3879
David M WoodBiomolecular Interaction Centre and School of Biological Sciences, University of Canterbury, Christchurch, New Zealand.
Amy HenricksonDepartment of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, AB, Canada.ORCID 0000-0003-3266-5202
Emre BrookesDepartment of Chemistry, University of Montana, Missoula, MT, USA.
Rachel A NorthBiomolecular Interaction Centre and School of Biological Sciences, University of Canterbury, Christchurch, New Zealand.
James M MurphyWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.ORCID 0000-0003-0195-3949
Rosmarie FriemannDepartment of Clinical Microbiology, Sahlgrenska University Hospital, Gothenburg, Sweden.ORCID 0000-0002-5633-2894
Michael D W GriffinBio21 Molecular Science and Biotechnology Institute, Department of Biochemistry and Pharmacology, University of Melbourne, Parkville, VIC, Australia.ORCID 0000-0001-9845-7735
Georg RammClive and Vera Ramaciotti Centre for Cryo-Electron Microscopy, Monash University, Clayton, VIC, Australia.ORCID 0000-0003-3596-2288
Borries DemelerDepartment of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, AB, Canada.ORCID 0000-0002-2414-9518
Renwick C J DobsonBiomolecular Interaction Centre and School of Biological Sciences, University of Canterbury, Christchurch, New Zealand. renwick.dobson@canterbury.ac.nz.ORCID 0000-0002-5506-4939
University of Canterbury · NZMonash University · AUThe University of Melbourne · AUUniversity of Lethbridge · CAAustralian Nuclear Science and Technology Organisation · AUBiotechnology Institute · USSahlgrenska University Hospital · SEUniversity of Montana · US

Funding

Development of an UltraScan Meta-Scheduler for HPC Job SubmissionR01GM120600 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Emre H. Brookes, BORRIES DEMELER · 2016 to 2026
$3.6M
NIGMS NIH HHS R01 GM120600
6 · The paper itself

Abstract

Bacteria respond to environmental changes by inducing transcription of some genes and repressing others. Sialic acids, which coat human cell surfaces, are a nutrient source for pathogenic and commensal bacteria. The Escherichia coli GntR-type transcriptional repressor, NanR, regulates sialic acid metabolism, but the mechanism is unclear. Here, we demonstrate that three NanR dimers bind a (GGTATA)

Indexed as

Allosteric RegulationBase SequenceBinding SitesCrystallography, X-RayDNA-Binding ProteinsEscherichia coliEscherichia coli ProteinsGene Expression Regulation, BacterialModels, MolecularN-Acetylneuraminic AcidNucleotide MotifsProtein BindingProtein ConformationProtein MultimerizationRepressor ProteinsSialic AcidsDNA-Binding ProteinsEscherichia coli ProteinsN-Acetylneuraminic AcidNanR protein, E coliRepressor ProteinsSialic Acids

Identifiers

PMID33790291
PMCPMC8012715
OpenAlexW3144308539

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.