ArticleNature communications2021
Statistics of pathogenic bacteria in the search of host cells.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Collective Response and Navigation Dynamics of Magnetospirillum gryphiswaldense under Rotating Magnetic Fields.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Optimal Chirality Enhances Long-Range Fluctuation-Induced Interactions in Active Fluids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Learning to Navigate in Chemical Fields Without A Map at Low Reynolds Numbers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Bacteria Optimize Tumble Bias to Strategically Navigate Surface Constraints.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Plant Microbe Interaction-Predicting the Pathogen Internalization Through Stomata Using Computational Neural Network Modeling.Foods (Basel, Switzerland) · 2024Article
- Surface conversion of the dynamics of bacteria escaping chemorepellents.The European physical journal. E, Soft matter · 2024Article
- Functional fibrillar interfaces: Biological hair as inspiration across scales.Beilstein journal of nanotechnology · 2024Review
- Self-Solidifying Active Droplets Showing Memory-Induced Chirality.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Reversible adhesion by type IV pili leads to formation of permanent localized clusters.iScience · 2022Article
- Article
- A motile doublet form of Salmonella Typhimurium diversifies target search behavior at the epithelial surface.Molecular microbiology · 2022Article
- Strain specific motility patterns and surface adhesion of virulent and probiotic Escherichia coli.Scientific reports · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A crucial phase in the infection process, which remains poorly understood, is the localization of suitable host cells by bacteria. It is often assumed that chemotaxis plays a key role during this phase. Here, we report a quantitative study on how Salmonella Typhimurium search for T84 human colonic epithelial cells. Combining time-lapse microscopy and mathematical modeling, we show that bacteria can be described as chiral active particles with strong active speed fluctuations, which are of biological, as opposed to thermal, origin. We observe that there exists a giant range of inter-individual variability of the bacterial exploring capacity. Furthermore, we find Salmonella Typhimurium does not exhibit biased motion towards the cells and show that the search time statistics is consistent with a random search strategy. Our results indicate that in vitro localization of host cells, and also cell infection, are random processes, not involving chemotaxis, that strongly depend on bacterial motility parameters.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.